The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas

XY Fu-Shin, PSY Lee, L Yang, N Gao, Y Zhang… - Progress in retinal and …, 2022 - Elsevier
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …

Biological functions of tear film

SC Pflugfelder, ME Stern - Experimental eye research, 2020 - Elsevier
Tears have a vital function to protect and lubricate the ocular surface. Tear production,
distribution and clearance is tightly regulated by the lacrimal functional unit (LFU) to meet …

Dry eye management: targeting the ocular surface microenvironment

X Zhang, V Jeyalatha M, Y Qu, X He, S Ou, J Bu… - International journal of …, 2017 - mdpi.com
Dry eye can damage the ocular surface and result in mild corneal epithelial defect to
blinding corneal pannus formation and squamous metaplasia. Significant progress in the …

Wound-healing studies in cornea and skin: parallels, differences and opportunities

A Bukowiecki, D Hos, C Cursiefen… - International journal of …, 2017 - mdpi.com
The cornea and the skin are both organs that provide the outer barrier of the body. Both
tissues have developed intrinsic mechanisms that protect the organism from a wide range of …

[图书][B] Adler's Physiology of the Eye: Expert Consult-Online and Print

LA Levin, SFE Nilsson, J Ver Hoeve, S Wu… - 2011 - books.google.com
Drs. Paul L. Kaufman, Albert Alm, Leonard A Levin, Siv FE Nilsson, James Ver Hoeve, and
Samuel Wu present the 11th Edition of the classic text Adler's Physiology of the Eye …

Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies

E Anitua, F Muruzabal, A Tayebba… - Acta …, 2015 - Wiley Online Library
The use of blood derivatives represents an alternative therapeutic approach that is gaining
interest in regenerative medicine due to its potential to stimulate and accelerate tissue …

Wounding the cornea to learn how it heals

MA Stepp, JD Zieske, V Trinkaus-Randall… - Experimental eye …, 2014 - Elsevier
Corneal wound healing studies have a long history and rich literature that describes the data
obtained over the past 70 years using many different species of animals and methods of …

ONSET-1 phase 2b randomized trial to evaluate the safety and efficacy of OC-01 (varenicline solution) nasal spray on signs and symptoms of dry eye disease

D Wirta, GL Torkildsen, B Boehmer, DA Hollander… - Cornea, 2022 - journals.lww.com
Purpose: The purpose of this trial was to evaluate the safety and efficacy of OC-01
(varenicline solution), a nicotinic acetylcholine receptor agonist nasal spray, on signs and …

Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications …

V Agrahari, PA Burnouf, T Burnouf… - Advanced Drug Delivery …, 2019 - Elsevier
Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic
indications, including neurodegenerative disorders. A broader understanding of the impact …

Plasma rich in growth factors (PRGF) eye drops stimulates scarless regeneration compared to autologous serum in the ocular surface stromal fibroblasts

E Anitua, M De la Fuente, F Muruzabal, A Riestra… - Experimental eye …, 2015 - Elsevier
Autologous serum (AS) eye drops was the first blood-derived product used for the treatment
of corneal pathologies but nowadays PRGF arises as a novel interesting alternative to this …