The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

BACKGROUND & AIMS: The neuropeptides calcitonin gene-related peptide (CGRP) and
substance P, and calcium channels, which control their release from extrinsic sensory …

Transient receptor potential (TRP) ion channels are emerging as a new set of membrane
proteins involved in a vast array of cellular processes and regulated by a large number of …

Biophysical cues from the cellular microenvironment are detected by mechanosensitive
machineries that translate physical signals into biochemical signaling cascades. At the …

The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion
channels that transduce mechanical stimuli with high sensitivity and speed. This conversion …

Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from
the primary tumor to distant organs. At the molecular level, migration is the result of several …

To date, 11 thermosensitive transient receptor potential (thermo-TRP) channels have been
identified. Recent studies have characterized the mechanism of thermosensing by thermo …