Sulfonamides are the basic motifs for a whole generation of drugs from a large group of
antibiotics. Currently, research in the field of the new sulfonamide synthesis has received a …

Imidazilidine-2, 4-dione, also well known as hydantoin (TH), is a prominent five-membered
heterocyclic compound with four versatile points of functionalities in its framework. Since the …

Inflammation is the main cause of several autoimmune diseases, including type I diabetes,
rheumatoid arthritis, bullous pemphigoid, paraneoplastic pemphigoid, and multiple …

The Biltz synthesis establishes straightforward access to 5, 5‐disubstituted (thio) hydantoins
by combining a 1, 2‐diketone and a (thio) urea. Its appealing features include inherent atom …

An efficient and practical N-arylation of hydantoins with substituted aryl/heteroaryl boronic
acids has been established, assisted by CuF2/MeOH under the base and ligand-free …

On the basis of the scaffolds widely used in drug design, a series of novel spirooxindole
derivatives containing hydantoin, thiohydantoin, urea, and thiourea moieties have been …

Novel fungicidal agents were designed based on the combination of two privileged
scaffolds, thiohydantoin and spirocyclic butenolide, which are widely found in natural …

We present the effective synthesis and structural characterization of three novel imidazolium-
thiohydantoin ligands (IMTHs, 5a–c) and their Mn (III) complexes (Mn (III) IMTHs, 6a–c) in …

Indoles and hydantoins are important heterocycles scaffolds which present in numerous
bioactive compounds which possess various biological activities. Moreover, they are …

In search for new and safer anti-cancer agents, a structurally guided pharmacophore
hybridization strategy of two privileged scaffolds, namely diaryl pyrazolines and …