The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …

Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

The cerebral cortex is at the core of brain functions that are thought to be particularly
developed in the human species. Human cortex specificities stem from divergent features of …

Primate genomics holds the key to understanding fundamental aspects of human evolution
and disease. However, genetic diversity and functional genomics data sets are currently …

Astrocytes are the key component of the central nervous system (CNS), serving as pivotal
regulators of neuronal synapse formation and maturation through their ability to dynamically …

The cerebral cortex—the brain's covering and largest region—has increased in size and
complexity in humans and supports higher cognitive functions such as language and …

Although the continual expansion of the brain during primate evolution accounts for our
enhanced cognitive capabilities, the drivers of brain evolution have scarcely been explored …

The cerebral cortex forms early in development according to a series of heritable
neurodevelopmental instructions. Despite deep evolutionary conservation of the cerebral …