Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …

Only one human disease that involves Mendelian inheritance of immunodeficiency and
aberrant DNA methylation has been identified. This is a rare chromosome breakage disease …

The recessive autosomal disorder known as ICF syndrome,,(for immunodeficiency,
centromere instability and facial anomalies; Mendelian Inheritance in Man number 242860) …

DNA methylation is an important regulator of genetic information in species ranging from
bacteria to humans. DNA methylation appears to be critical for mammalian development …

Programmed methylation and demethylation of regulatory sequences has been proposed to
play a central role in vertebrate development. We report here that the methylation status of …

Prenatal synthetic glucocorticoids (sGC) are administered to pregnant women at risk of
delivering preterm, approximately 10% of all pregnancies. Animal studies have …

Immunodeficiency with centromeric instability and facial anomalies (ICF) syndrome is a
primary immunodeficiency, predominantly characterized by agammaglobulinemia or …

Changes in brain structure and cortical function are associated with many chronic pain
conditions including low back pain and fibromyalgia. The magnitude of these changes …

DNA methylation is a major determinant in the epigenetic silencing of genes. The
mechanisms underlying the targeting of DNA methylation and the subsequent repression of …

Rearrangements in the vicinity of the centromere of chromosome 1 are over-represented in
many types of human cancer and are a characteristic feature of a rare genetic disease called …