Cancer stem cell (CSC) resistance drivers

M Najafi, K Mortezaee, J Majidpoor - Life sciences, 2019 - Elsevier
Cancer stem cells (CSCs) are a population of self-renewal cells with high tumorigenic
potency. CSCs can adopt easily with changes in the nearby milieu, and are more resistant to …

Recent insights into the microRNA and long non-coding RNA-mediated regulation of stem cell populations

C Estrada-Meza, A Torres-Copado… - 3 Biotech, 2022 - Springer
Stem cells are undifferentiated cells that have multi-lineage differentiation. The transition
from self-renewal to differentiation requires rapid and extensive gene expression alterations …

Identification of novel SARS-CoV-2 drug targets by host microRNAs and transcription factors co-regulatory interaction network analysis

R Sardar, D Satish, D Gupta - Frontiers in genetics, 2020 - frontiersin.org
Understanding the host regulatory mechanisms opposing virus infection and virulence can
provide actionable insights to identify novel therapeutics against severe acute respiratory …

Identification of potential microRNA diagnostic panels and uncovering regulatory mechanisms in breast cancer pathogenesis

Z Sharifi, M Talkhabi, S Taleahmad - Scientific Reports, 2022 - nature.com
Early diagnosis of breast cancer (BC), as the most common cancer among women,
increases the survival rate and effectiveness of treatment. MicroRNAs (miRNAs) control …

Anticancer Effect of Polyphyllin I in Suppressing Stem Cell‐Like Properties of Hepatocellular Carcinoma via the AKT/GSK‐3β/β‐Catenin Signaling Pathway

M Liao, H Du, B Wang, J Huang… - … Medicine and Cellular …, 2022 - Wiley Online Library
Polyphyllin I (PPI), also called Chong Lou saponin I, is a steroidal saponin isolated from the
rhizome of Paris polyphylla. PPI has been demonstrated to have strong anticancer activity …

HIPPO signaling-related signature for predicting prognosis and therapeutic response in gastric cancer

R Jiang, J Wang, J Liang, D Lin, Q Mao… - Frontiers in …, 2023 - frontiersin.org
Background: Gastric cancer (GC) is a multifactorial progressive disease with high mortality
and heterogeneous prognosis. Effective prognostic biomarkers for GC were critically …

Targeted delivery of miR-218 via decorated hyperbranched polyamidoamine for liver cancer regression

AM Elfiky, RH Mohamed, FEZ Abd EL-Hakam… - International Journal of …, 2021 - Elsevier
Hepatocellular carcinoma (HCC) is one of most common causes of cancer death worldwide.
MicroRNA (miRNA) replacement gene therapy is a novel approach for HCC management …

[HTML][HTML] Dairy consumption and hepatocellular carcinoma risk

BC Melnik - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
This review provides epidemiological and translational evidence for milk and dairy intake as
critical risk factors in the pathogenesis of hepatocellular carcinoma (HCC). Large …

Hepatocellular carcinoma cell line-microenvironment induced cancer-associated phenotype, genotype and functionality in mesenchymal stem cells

RA Salah, MA Nasr, AM El-Derby, M Abd Elkodous… - Life Sciences, 2022 - Elsevier
Mesenchymal stromal cells (MSCs) have shown promise in liver cancer treatment. However,
when MSCs are recruited to hepatic site of injury, they acquire cancerous promoting …

Guest Edited Collection: Epigenetics within the tumor microenvironment

A Ahmad - Scientific Reports, 2022 - nature.com
The tumor microenvironment (TME) comprises of components that exist within the immediate
vicinity of tumor cells, including fibroblasts, immune cells, the extracellular matrix, and more …