Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

Regenerative approaches have made such a great progress, now aiming toward replacing
the exact neurons lost upon injury or neurodegeneration. Transplantation and direct …

Cell transplantation is a promising approach for the reconstruction of neuronal circuits after
brain damage. Transplanted neurons integrate with remarkable specificity into circuitries of …

Stem cell therapy using human skin-derived neural precursors holds much promise for the
treatment of stroke patients. Two main mechanisms have been proposed to give rise to the …

The risk of having a stroke event doubles each decade after the age of 55. Therefore, it is of
great interest to develop neurorestorative therapies of stroke which occurs mostly in elderly …

Loss of nervous system tissue after severe brain injury is a main determinant of poor
functional recovery. Cell transplantation is a promising method to restore lost tissue and …

Traumatic brain injury (TBI) is the main cause of disability, mental health disorder, and even
death, with its incidence and social costs rising steadily. Although different treatment …

Recent biotechnological innovations make feasible the new paradigm of creating biological
neural circuits de novo. With advances in protein, cell and tissue engineering techniques, as …