Brillouin microscopy: an emerging tool for mechanobiology
The role and importance of mechanical properties of cells and tissues in cellular function,
development and disease has widely been acknowledged, however standard techniques …
development and disease has widely been acknowledged, however standard techniques …
Mechanical adaptability of tumor cells in metastasis
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …
successfully form life-threatening metastases when they undergo sequential steps along a …
Physical phenotype of blood cells is altered in COVID-19
M Kubánková, B Hohberger, J Hoffmanns, J Fürst… - Biophysical journal, 2021 - cell.com
Clinical syndrome coronavirus disease 2019 (COVID-19) induced by severe acute
respiratory syndrome coronavirus 2 is characterized by rapid spreading and high mortality …
respiratory syndrome coronavirus 2 is characterized by rapid spreading and high mortality …
Mechanics, malignancy, and metastasis: the force journey of a tumor cell
A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …
Direct evidence that tumor cells soften when navigating confined spaces
The mechanical properties of cells strongly regulate many physiological and pathological
processes. For example, in cancer, invasive and metastatic tumor cells have often been …
processes. For example, in cancer, invasive and metastatic tumor cells have often been …
Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood
Blood is arguably the most important bodily fluid and its analysis provides crucial health
status information. A first routine measure to narrow down diagnosis in clinical practice is the …
status information. A first routine measure to narrow down diagnosis in clinical practice is the …
Placental syncytium forms a biophysical barrier against pathogen invasion
VB Zeldovich, CH Clausen, E Bradford… - PLoS …, 2013 - journals.plos.org
Fetal syncytiotrophoblasts form a unique fused multinuclear surface that is bathed in
maternal blood, and constitutes the main interface between fetus and mother …
maternal blood, and constitutes the main interface between fetus and mother …
Passive circulating cell sorting by deformability using a microfluidic gradual filter
P Preira, V Grandne, JM Forel, S Gabriele, M Camara… - Lab on a Chip, 2013 - pubs.rsc.org
The deformability of circulating leukocytes plays an important role in the physiopathology of
several diseases like sepsis or acute respiratory distress syndrome (ARDS). We present …
several diseases like sepsis or acute respiratory distress syndrome (ARDS). We present …
Single-Cell Mechanics: Structural Determinants and Functional Relevance
M Urbanska, J Guck - Annual Review of Biophysics, 2024 - annualreviews.org
The mechanical phenotype of a cell determines its ability to deform under force and is
therefore relevant to cellular functions that require changes in cell shape, such as migration …
therefore relevant to cellular functions that require changes in cell shape, such as migration …
Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph)
Pathophysiological landmarks of depressive disorders are chronic low-grade inflammation
and elevated glucocorticoid output. Both can potentially interfere with cytoskeleton …
and elevated glucocorticoid output. Both can potentially interfere with cytoskeleton …