Polystyrene microplastics (PS-MPs) can threaten human health, especially male fertility.
However, most existing studies have focused on the adulthood stage of male reproduction …

Dynamic chromatin accessibility regulates stem cell fate determination and tissue
homeostasis via controlling gene expression. As a histone‐modifying enzyme that …

The ovarian reserve defines female reproductive lifespan, which in humans spans decades.
The ovarian reserve consists of oocytes residing in primordial follicles arrested in meiotic …

Highly potent animal stem cells either self renew or launch complex differentiation programs,
using mechanisms that are only partly understood. Drosophila female germline stem cells …

Highlights•Epigenome regulating gene expression programs underlies male germ cell
identity and spermatogenesis.•Epigenetic priming ensure the maintenance of male germ …

Background Cholangiocarcinoma (CCA) refers to a collection of malignancies that are
associated with a dismal prognosis. Currently, surgical resection is the only way to cure …

Epigenetics play major roles in the regulation of cellular identity. This chapter serves to
describe our collective progress in understanding the epigenetic dynamics and regulators …

Initiating soon after PGC specification, female germ cells undergo reactivation of the
silenced X chromosome during genome wide reprogramming. However, the kinetics and …

Sexual reproduction is a common feature of multicellular eukaryotic species, involving the
fusion of two haploid gametes to transmit genetic information between generations. In …

One of the most crucial cell lineage decisions in mammalian embryos is the differentiation of
a few pluripotent epiblast cells into primordial germ cells (PGCs). PGCs are unique for their …