Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine

ME Fini, SG Schwartz, X Gao, S Jeong, N Patel… - Progress in retinal and …, 2017 - Elsevier
Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …

The role of steroids in outflow resistance

AF Clark, RJ Wordinger - Experimental eye research, 2009 - Elsevier
Glucocorticoid (GC)-induced ocular hypertension and secondary iatrogenic open-angle
glaucoma are serious side effects of GC therapy. Its clinical presentation is similar in many …

Gene mapping for primary open angle glaucoma

BJ Fan, DY Wang, DSC Lam, CP Pang - Clinical biochemistry, 2006 - Elsevier
Primary open angle glaucoma (POAG) is a leading cause of visual impairment and
blindness worldwide. To date, at least 20 genetic loci for POAG have been reported. Only 3 …

Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress‐signalling pathways

JJ Wolfson, KL May, CM Thorpe… - Cellular …, 2008 - Wiley Online Library
Subtilase cytotoxin (SubAB) is the prototype of a new family of AB5 cytotoxins produced by
Shiga toxigenic Escherichia coli. Its cytotoxic activity is due to its capacity to enter cells and …

Persisent ocular hypertension following intravitreal ranibizumab

SJ Bakri, CA McCannel, AO Edwards… - Graefe's archive for …, 2008 - Springer
Background To describe the occurrence of ocular hypertension in four patients following
injection of ranibizumab intravitreally. Methods Case series. Results Four patients had high …

Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment

M Gemenetzi, Y Yang, AJ Lotery - Eye, 2012 - nature.com
Glaucoma is a common, complex, heterogenous disease and it constitutes the major cause
of irreversible blindness worldwide. Primary open-angle glaucoma (POAG) is the most …

Sustained elevation of intraocular pressure after intravitreal anti-VEGF agents: what is the evidence?

VS Dedania, SJ Bakri - Retina, 2015 - journals.lww.com
Purpose: To summarize the literature addressing sustained and delayed elevation of
intraocular pressure (IOP) in patients with neovascular age-related macular degeneration …

Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular …

A Nehmé, EK Lobenhofer, WD Stamer… - BMC medical …, 2009 - Springer
Background In addition to their well-documented ocular therapeutic effects, glucocorticoids
(GCs) can cause sight-threatening side-effects including ocular hypertension presumably …

[PDF][PDF] Gene expression profile of human trabecular meshwork cells in response to long-term dexamethasone exposure

FW Rozsa, DM Reed, KM Scott, H Pawar, SE Moroi… - Mol Vis, 2006 - molvis.org
v12a14-rozsa pgmkr Page 1 Molecular Vision 2006; 12:125-41 <http://www.molvis.org/molvis/v12/a14/>
Received 4 November 2005 | Accepted 16 February 2006 | Published 27 February 2006 …

Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells

R Clark, A Nosie, T Walker, JA Faralli, MS Filla… - Molecular & Cellular …, 2013 - ASBMB
Changes in the actin cytoskeleton, especially the formation of cross-linked actin networks
(CLANs) are thought to contribute to the increased intraocular pressure observed in primary …