Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
ME Fini, SG Schwartz, X Gao, S Jeong, N Patel… - Progress in retinal and …, 2017 - Elsevier
Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …
The role of steroids in outflow resistance
AF Clark, RJ Wordinger - Experimental eye research, 2009 - Elsevier
Glucocorticoid (GC)-induced ocular hypertension and secondary iatrogenic open-angle
glaucoma are serious side effects of GC therapy. Its clinical presentation is similar in many …
glaucoma are serious side effects of GC therapy. Its clinical presentation is similar in many …
Gene mapping for primary open angle glaucoma
Primary open angle glaucoma (POAG) is a leading cause of visual impairment and
blindness worldwide. To date, at least 20 genetic loci for POAG have been reported. Only 3 …
blindness worldwide. To date, at least 20 genetic loci for POAG have been reported. Only 3 …
Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress‐signalling pathways
JJ Wolfson, KL May, CM Thorpe… - Cellular …, 2008 - Wiley Online Library
Subtilase cytotoxin (SubAB) is the prototype of a new family of AB5 cytotoxins produced by
Shiga toxigenic Escherichia coli. Its cytotoxic activity is due to its capacity to enter cells and …
Shiga toxigenic Escherichia coli. Its cytotoxic activity is due to its capacity to enter cells and …
Persisent ocular hypertension following intravitreal ranibizumab
Background To describe the occurrence of ocular hypertension in four patients following
injection of ranibizumab intravitreally. Methods Case series. Results Four patients had high …
injection of ranibizumab intravitreally. Methods Case series. Results Four patients had high …
Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment
M Gemenetzi, Y Yang, AJ Lotery - Eye, 2012 - nature.com
Glaucoma is a common, complex, heterogenous disease and it constitutes the major cause
of irreversible blindness worldwide. Primary open-angle glaucoma (POAG) is the most …
of irreversible blindness worldwide. Primary open-angle glaucoma (POAG) is the most …
Sustained elevation of intraocular pressure after intravitreal anti-VEGF agents: what is the evidence?
VS Dedania, SJ Bakri - Retina, 2015 - journals.lww.com
Purpose: To summarize the literature addressing sustained and delayed elevation of
intraocular pressure (IOP) in patients with neovascular age-related macular degeneration …
intraocular pressure (IOP) in patients with neovascular age-related macular degeneration …
Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular …
A Nehmé, EK Lobenhofer, WD Stamer… - BMC medical …, 2009 - Springer
Background In addition to their well-documented ocular therapeutic effects, glucocorticoids
(GCs) can cause sight-threatening side-effects including ocular hypertension presumably …
(GCs) can cause sight-threatening side-effects including ocular hypertension presumably …
[PDF][PDF] Gene expression profile of human trabecular meshwork cells in response to long-term dexamethasone exposure
v12a14-rozsa pgmkr Page 1 Molecular Vision 2006; 12:125-41 <http://www.molvis.org/molvis/v12/a14/>
Received 4 November 2005 | Accepted 16 February 2006 | Published 27 February 2006 …
Received 4 November 2005 | Accepted 16 February 2006 | Published 27 February 2006 …
Comparative genomic and proteomic analysis of cytoskeletal changes in dexamethasone-treated trabecular meshwork cells
R Clark, A Nosie, T Walker, JA Faralli, MS Filla… - Molecular & Cellular …, 2013 - ASBMB
Changes in the actin cytoskeleton, especially the formation of cross-linked actin networks
(CLANs) are thought to contribute to the increased intraocular pressure observed in primary …
(CLANs) are thought to contribute to the increased intraocular pressure observed in primary …