Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy
AJ Marian, E Braunwald - Circulation research, 2017 - Am Heart Assoc
Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …
Hypertrophic cardiomyopathy: the future of treatment
CV Tuohy, S Kaul, HK Song, B Nazer… - European journal of …, 2020 - Wiley Online Library
Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic disorder most often caused
by sarcomeric mutations resulting in left ventricular hypertrophy, fibrosis, hypercontractility …
by sarcomeric mutations resulting in left ventricular hypertrophy, fibrosis, hypercontractility …
Mechanisms of disease: hypertrophic cardiomyopathy
N Frey, M Luedde, HA Katus - Nature Reviews Cardiology, 2012 - nature.com
Hypertrophic cardiomyopathy (HCM) is the most-common monogenically inherited form of
heart disease, characterized by thickening of the left ventricular wall, contractile dysfunction …
heart disease, characterized by thickening of the left ventricular wall, contractile dysfunction …
Reactive oxygen species controls endometriosis progression
Endometriosis is associated with chronic inflammation, and reactive oxygen species (ROS)
are proinflammatory mediators that modulate cell proliferation. We have investigated …
are proinflammatory mediators that modulate cell proliferation. We have investigated …
Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
Progress in precision medicine is limited by insufficient knowledge of transcriptomic or
proteomic features in involved tissues that define pathobiological differences between …
proteomic features in involved tissues that define pathobiological differences between …
Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence
R Spoladore, MS Maron, R D'Amato… - European heart …, 2012 - academic.oup.com
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, affecting
over one million individuals in Europe. Hypertrophic cardiomyopathy patients often require …
over one million individuals in Europe. Hypertrophic cardiomyopathy patients often require …
Pharmacological management of hypertrophic cardiomyopathy: from bench to bedside
C Palandri, L Santini, A Argirò, F Margara, R Doste… - Drugs, 2022 - Springer
Hypertrophic cardiomyopathy (HCM), the most common inherited heart disease, is still
orphan of a specific drug treatment. The erroneous consideration of HCM as a rare disease …
orphan of a specific drug treatment. The erroneous consideration of HCM as a rare disease …
[HTML][HTML] Hypertrophic cardiomyopathy: genetics and clinical perspectives
CM Wolf - Cardiovascular diagnosis and therapy, 2019 - ncbi.nlm.nih.gov
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and
defined by unexplained isolated progressive myocardial hypertrophy, systolic and diastolic …
defined by unexplained isolated progressive myocardial hypertrophy, systolic and diastolic …
Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy
H Ashrafian, WJ McKenna, H Watkins - Circulation research, 2011 - Am Heart Assoc
As described in earlier reviews in this series on the molecular basis of hypertrophic
cardiomyopathy (HCM), HCM is one of the archetypal monogenic cardiovascular disorders …
cardiomyopathy (HCM), HCM is one of the archetypal monogenic cardiovascular disorders …
N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation
C Li, N Xie, Y Li, C Liu, FF Hou, J Wang - Free Radical Biology and …, 2019 - Elsevier
The mechanism underlying the development of chronic kidney disease (CKD) after acute
kidney injury (AKI) remains unclear. Maladaptive repair has been considered an important …
kidney injury (AKI) remains unclear. Maladaptive repair has been considered an important …