Colon cancer is a major human cancer accounting for about a tenth of all cancer cases thus
making it among the top three cancers in terms of incidence as well as mortality. Metastasis …

Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …

The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

There are limited options for patients who develop liver metastasis from colorectal cancer
(CRC), the leading cause of cancer-related mortality worldwide. Emerging evidence has …

Uncontrollable metastatic outgrowth process is the leading cause of mortality worldwide,
even in the case of colorectal cancer. Colorectal cancer (CRC) accounts for approximately …

The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this
review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming …

RIP1 (receptor-interacting protein kinase 1) is an important component of TNF-α signaling
that contributes to various pathological effects. Here, we revealed new potential roles of …

Programmed death ligand 1 (PD‐L1) plays a significant role in colorectal tumorigenesis
through induction of regulatory T cells (Tregs) and suppression of antitumor immunity …

Cancer remains one of the leading causes of death worldwide despite significant
therapeutic advancements and improved detection methods. Nucleic acid (NA) therapeutics …

Background The active metabolite of 5-Fluorouracil (5FU), used in the treatment of several
types of cancer, acts by inhibiting the thymidylate synthase encoded by the TYMS gene …