Background The past two decades have witnessed an epidemic of opioid use disorder
(OUD) in the USA, resulting in catastrophic loss of life secondary to opioid overdoses …

Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

Substance use disorders (SUDs) are highly prevalent and exact a large toll on individuals'
health, well‐being, and social functioning. Long‐lasting changes in brain networks involved …

Opioid use disorder (OUD) is a chronic and relapsing condition that involves the continued
and compulsive use of opioids despite harmful consequences. The development of …

This review article offers an outlook on the use of opioids as therapeutics for treating several
diseases, including cancer and non-cancer pain, and focuses the analysis on the …

Substance use disorder (SUD) is a global public health concern that affects millions of
people worldwide. Considering current research, addiction has been noted as the last stage …

Opioid abuse and related overdose deaths continue to rise in the United States, contributing
to the current national opioid crisis. Although several opioid-based pharmacotherapies are …

Abstract Background Medications for Opioid Use Disorder (MOUD) are efficacious, however
only one-third of individuals with an opioid use disorder (OUD) enter into treatment. Low …

Opioid use disorder (OUD) continuously poses major public health challenges and social
implications worldwide with dramatic rise of opioid dependence leading to potential abuse …

Background At low doses, naltrexone (LDN) has been shown to modulate inflammation
through the interruption of microglial cell activation within the central nervous system. One of …