Inflammasomes are components of the innate immune response that have recently emerged
as crucial controllers of tissue homeostasis. In particular, the nucleotide-binding domain …

Cytokines play a crucial role in the structure and function of blood vessels in hypertension.
Hypertension damages blood vessels by mechanisms linked to shear forces, activation of …

Dietary salt reduction and exercise are lifestyle modifications for salt-sensitive
hypertensives. While exercise has prominent metabolic effects, salt has an adverse effect on …

Significance: Salt sensitivity of blood pressure (SSBP) is an independent risk factor for
mortality and morbidity due to cardiovascular disease, and disproportionately affects blacks …

Sepsis is a life threatening disease that is caused by a dysregulated host immune response
to infection, resulting in tissue damage and organ dysfunction, which account for a high in …

The immune system plays a prominent role in the initiation and maintenance of
hypertension. The innate immune system, via toll‐like receptors (TLRs), identifies distinct …

Background: Hypertension is a multifactorial and chronic cardiovascular condition whose
complications are responsible for worldwide morbidity and mortality. An increasing body of …

Studies of Dahl salt-sensitive (SS) rats have shown that renal CD3+ T cells and ED-1+
macrophages are involved in the development of salt-sensitive hypertension and renal …

Hypertensive nephropathy (HTN) is the second leading cause of end-stage renal disease
(ESRD) and a chronic inflammatory disease. Persistent hypertension leads to lesions of …

Essential hypertension (EH) is a highly heterogenous disease with a complex etiology.
Recent evidence highlights the significant contribution of subclinical inflammation, triggered …