Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Positron emission tomography (PET) uses radioactive tracers and enables the functional
imaging of several metabolic processes, blood flow measurements, regional chemical …

A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …

Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread
musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests a …

The potential for positron emission tomography (PET) to detect neuroinflammation in vivo
has sparked a remarkable interest in various disciplines of neuroscience. Early PET …

Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell
types are likely involved in this disease. We recently generated rNLS8 mice in which human …

The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …