[HTML][HTML] Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish

NJ Niemuth, RD Klaper - Chemosphere, 2015 - Elsevier
The occurrence of intersex fish, where male reproductive tissues show evidence of
feminization, have been found in freshwater systems around the world, indicating the …

Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin

AA Godoy, I Domingues, AJA Nogueira… - Environmental …, 2018 - Elsevier
Metformin (MET) is among the most consumed pharmaceuticals worldwide. This compound
has been frequently detected in fresh surface water. However, ecotoxicological information …

Metformin-induced endocrine disruption and oxidative stress of Oryzias latipes on two-generational condition

JW Lee, YJ Shin, H Kim, H Kim, J Kim, SA Min… - Journal of Hazardous …, 2019 - Elsevier
Metformin has been treated for diabetes (type 2). Nowadays, this compound is frequently
found in ambient water, influent/effluent of a wastewater treatment plant. To evaluate the …

Role of kinetic models in drug stability

Q Rehman, MSH Akash, MF Rasool… - Drug Stability and …, 2020 - Springer
Kinetic models are studied to determine their role in stability and release kinetics of drugs.
The mathematical models that have been widely used are zero-order kinetic model, first …

Mild chemo-photothermal synergistic therapy for tumors based on gold-nanoparticles coupled with metformin

T Yang, H Wang, Q Zhou, W Huang… - ACS Applied Nano …, 2023 - ACS Publications
The past decades have witnessed great achievements in the synergistic therapy for tumors,
especially chemo-photothermal synergistic therapy. However, due to the high working …

Occurrence, impact, analysis and treatment of metformin and guanylurea in coastal aquatic environments of Canada, USA and Europe

Y Tao, B Chen, BH Zhang, ZJ Zhu, Q Cai - Advances in Marine Biology, 2018 - Elsevier
This review discusses the occurrence, impact, analysis and treatment of metformin and
guanylurea in coastal aquatic environments of Canada, USA and Europe. Metformin, a …

Age-dependent effects in fathead minnows from the anti-diabetic drug metformin

J Crago, C Bui, S Grewal, D Schlenk - General and comparative …, 2016 - Elsevier
The anti-diabetic drug metformin is thought to be the pharmaceutical most deposited into the
aquatic environment by mass at up to 6 tons per year from individual WWTPs in urban areas …

Metformin-induced alterations in gills of the freshwater fish Astyanax lacustris (Lütken, 1875) detected by histological and scanning electron microscopy

PA Barbieri, IP Mari-Ribeiro, L Lupepsa, AAS Gigliolli… - Ecotoxicology, 2022 - Springer
The antidiabetic drug metformin is widely prescribed and found in different concentrations in
the environment around the world, raising concern about potential impacts on aquatic life …

Theoretical and experimental investigation on the intercalation of metformin into layered clay minerals

EP Rebitski, M Darder, CI Sainz-Diaz, R Carraro… - Applied Clay …, 2020 - Elsevier
This work introduces a comparative study on the use of two layered clays, a natural
Wyoming montmorillonite (commercialized as Cloisite® Na; Mt) and a synthetic hectorite …

The combination of metformin and valproic acid has a greater anti-tumoral effect on prostate cancer growth in vivo than either drug alone

LNK Tran, G Kichenadasse, KL Morel, TC Lavranos… - in vivo, 2019 - iv.iiarjournals.org
Background/Aim: The hypoglycemic drug metformin (MET) and the anti-epileptic drug
valproic acid (VPA) have individually shown anti-tumor effects in prostate cancer in vitro. The …