Oligosaccharide synthesis and translational innovation

L Krasnova, CH Wong - Journal of the American Chemical Society, 2019 - ACS Publications
The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …

Toward automated enzymatic synthesis of oligosaccharides

L Wen, G Edmunds, C Gibbons, J Zhang… - Chemical …, 2018 - ACS Publications
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …

Human milk oligosaccharides (HMOS): structure, function, and enzyme-catalyzed synthesis

X Chen - Advances in carbohydrate chemistry and biochemistry, 2015 - Elsevier
The important roles played by human milk oligosaccharides (HMOS), the third major
component of human milk, in the health of breast-fed infants have been increasingly …

Development of Globo-H cancer vaccine

SJ Danishefsky, YK Shue, MN Chang… - Accounts of chemical …, 2015 - ACS Publications
Conspectus The development of anticancer vaccines requires the identification of unique
epitope markers, preferably expressed exclusively on the surface of cancer cells. This …

Leloir glycosyltransferases as biocatalysts for chemical production

B Nidetzky, A Gutmann, C Zhong - ACS Catalysis, 2018 - ACS Publications
Glycosylation is a chemical transformation that is centrally important in all glycoscience and
related technologies. Catalysts offering good control over reactivity and selectivity in …

Biotechnological advances in UDP-sugar based glycosylation of small molecules

F De Bruyn, J Maertens, J Beauprez, W Soetaert… - Biotechnology …, 2015 - Elsevier
Glycosylation of small molecules like specialized (secondary) metabolites has a profound
impact on their solubility, stability or bioactivity, making glycosides attractive compounds as …

Leloir glycosyltransferases in applied biocatalysis: A multidisciplinary approach

L Mestrom, M Przypis, D Kowalczykiewicz… - International journal of …, 2019 - mdpi.com
Enzymes are nature's catalyst of choice for the highly selective and efficient coupling of
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …

Prophylactic cancer vaccines engineered to elicit specific adaptive immune response

DW Crews, JA Dombroski, MR King - Frontiers in Oncology, 2021 - frontiersin.org
Vaccines have been used to prevent and eradicate different diseases for over 200 years,
and new vaccine technologies have the potential to prevent many common illnesses …

Chemical biology approaches to designing defined carbohydrate vaccines

C Anish, B Schumann, CL Pereira, PH Seeberger - Chemistry & biology, 2014 - cell.com
Carbohydrate antigens have shown promise as important targets for developing effective
vaccines and pathogen detection strategies. Modifying purified microbial glycans through …

Understanding the chemistry and biology of glycosylation with glycan synthesis

L Krasnova, CH Wong - Annual review of biochemistry, 2016 - annualreviews.org
Glycoscience research has been significantly impeded by the complex compositions of the
glycans present in biological molecules and the lack of convenient tools suitable for studying …