Oligosaccharide synthesis and translational innovation
L Krasnova, CH Wong - Journal of the American Chemical Society, 2019 - ACS Publications
The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …
Toward automated enzymatic synthesis of oligosaccharides
Oligosaccharides together with oligonucleotides and oligopeptides comprise the three major
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
classes of natural biopolymers. Automated systems for oligonucleotide and oligopeptide …
Human milk oligosaccharides (HMOS): structure, function, and enzyme-catalyzed synthesis
X Chen - Advances in carbohydrate chemistry and biochemistry, 2015 - Elsevier
The important roles played by human milk oligosaccharides (HMOS), the third major
component of human milk, in the health of breast-fed infants have been increasingly …
component of human milk, in the health of breast-fed infants have been increasingly …
Development of Globo-H cancer vaccine
SJ Danishefsky, YK Shue, MN Chang… - Accounts of chemical …, 2015 - ACS Publications
Conspectus The development of anticancer vaccines requires the identification of unique
epitope markers, preferably expressed exclusively on the surface of cancer cells. This …
epitope markers, preferably expressed exclusively on the surface of cancer cells. This …
Leloir glycosyltransferases as biocatalysts for chemical production
Glycosylation is a chemical transformation that is centrally important in all glycoscience and
related technologies. Catalysts offering good control over reactivity and selectivity in …
related technologies. Catalysts offering good control over reactivity and selectivity in …
Biotechnological advances in UDP-sugar based glycosylation of small molecules
F De Bruyn, J Maertens, J Beauprez, W Soetaert… - Biotechnology …, 2015 - Elsevier
Glycosylation of small molecules like specialized (secondary) metabolites has a profound
impact on their solubility, stability or bioactivity, making glycosides attractive compounds as …
impact on their solubility, stability or bioactivity, making glycosides attractive compounds as …
Leloir glycosyltransferases in applied biocatalysis: A multidisciplinary approach
L Mestrom, M Przypis, D Kowalczykiewicz… - International journal of …, 2019 - mdpi.com
Enzymes are nature's catalyst of choice for the highly selective and efficient coupling of
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …
carbohydrates. Enzymatic sugar coupling is a competitive technology for industrial …
Prophylactic cancer vaccines engineered to elicit specific adaptive immune response
Vaccines have been used to prevent and eradicate different diseases for over 200 years,
and new vaccine technologies have the potential to prevent many common illnesses …
and new vaccine technologies have the potential to prevent many common illnesses …
Chemical biology approaches to designing defined carbohydrate vaccines
Carbohydrate antigens have shown promise as important targets for developing effective
vaccines and pathogen detection strategies. Modifying purified microbial glycans through …
vaccines and pathogen detection strategies. Modifying purified microbial glycans through …
Understanding the chemistry and biology of glycosylation with glycan synthesis
L Krasnova, CH Wong - Annual review of biochemistry, 2016 - annualreviews.org
Glycoscience research has been significantly impeded by the complex compositions of the
glycans present in biological molecules and the lack of convenient tools suitable for studying …
glycans present in biological molecules and the lack of convenient tools suitable for studying …