For about four decades, platelet-derived growth factors (PDGF) and their receptors have
been the subject of intense research, revealing their roles in embryo development and …

Platelet-derived growth factor-BB (PDGF-BB): PDGF receptor-β (PDGFRβ) signalling in
brain pericytes is critical to the development, maintenance and function of a healthy blood …

Tyrosine phosphorylation, orchestrated by tyrosine kinases and phosphatases, modulates a
multi-layered signaling network in a time-and space-dependent manner. Dysregulation of …

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and a high mortality rate.
The transcription factor YY1 acts as an inhibitor of many types of tumors. We found that YY1 …

Aberrant overexpression of nonreceptor tyrosine kinase FER (Fps/Fes Related) has been
reported in various ovarian carcinoma–derived tumor cells and is a poor prognosis factor for …

Platelet‐derived growth factors (PDGF) bind to two related receptor tyrosine kinases, which
are encoded by the PDGFRA and PDGFRB genes. Recently, heterozygous PDGFRB …

Stromal cell‑derived growth factor (SDF)‑1α acts as a ligand to C‑X‑C chemokine receptors 4
(CXCR4) and 7 (CXCR7), which are involved in the formation of choroidal …

Nicotinamide phosphoribosyltransferase (NAMPT), a pleiotropic protein, promotes the
proliferation and migration of pulmonary artery smooth muscle cells (PASMCs), which is …

Protein ubiquitination controls protein stability and subcellular localization of tyrosine kinase
receptors, hence affecting signaling both quantitatively and qualitatively. In this report, we …

Translocation of full-length or fragments of receptors to the nucleus has been reported for
several tyrosine kinase receptors. In this paper, we show that a fraction of full-length cell …