Chemical discovery in the era of metabolomics

M Sindelar, GJ Patti - Journal of the American Chemical Society, 2020 - ACS Publications
Untargeted metabolomics aims to quantify the complete set of metabolites within a biological
system, most commonly by liquid chromatography/mass spectrometry (LC/MS). Since nearly …

Starvation Responses Throughout the Caenorhabditis  elegans Life Cycle

LR Baugh, PJ Hu - Genetics, 2020 - academic.oup.com
Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …

A neurotransmitter produced by gut bacteria modulates host sensory behaviour

MP O'Donnell, BW Fox, PH Chao, FC Schroeder… - Nature, 2020 - nature.com
Animals coexist in commensal, pathogenic or mutualistic relationships with complex
communities of diverse organisms, including microorganisms. Some bacteria produce …

Chemosensory signal transduction in Caenorhabditis elegans

DM Ferkey, P Sengupta, ND L'Etoile - Genetics, 2021 - academic.oup.com
Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

Balancing selection shapes density-dependent foraging behaviour

JS Greene, M Brown, M Dobosiewicz, IG Ishida… - Nature, 2016 - nature.com
The optimal foraging strategy in a given environment depends on the number of competing
individuals and their behavioural strategies. Little is known about the genes and neural …

Parallel pathways for serotonin biosynthesis and metabolism in C. elegans

J Yu, MC Vogt, BW Fox, CJJ Wrobel… - Nature chemical …, 2023 - nature.com
The neurotransmitter serotonin plays a central role in animal behavior and physiology, and
many of its functions are regulated via evolutionarily conserved biosynthesis and …

C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues

J Luo, C Bainbridge, RM Miller, A Barrios, DS Portman - Current Biology, 2024 - cell.com
For sexually reproducing animals, selecting optimal mates is important for maximizing
reproductive fitness. In the nematode C. elegans, populations reproduce largely by …

Regulation and modulation of biogenic amine neurotransmission in Drosophila and Caenorhabditis elegans

KD Rosikon, MC Bone, HO Lawal - Frontiers in Physiology, 2023 - frontiersin.org
Neurotransmitters are crucial for the relay of signals between neurons and their target.
Monoamine neurotransmitters dopamine (DA), serotonin (5-HT), and histamine are found in …

Mass spectrometric evaluation of mephedrone in vivo human metabolism: identification of phase I and phase II metabolites, including a novel succinyl conjugate

ÓJ Pozo, M Ibáñez, JV Sancho… - Drug Metabolism and …, 2015 - ASPET
In recent years, many new designer drugs have emerged, including the group of cathinone
derivatives. One frequently occurring drug is mephedrone; although mephedrone was …

A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk

N Li, B Hua, Q Chen, F Teng, M Ruan, M Zhu, L Zhang… - Cell reports, 2022 - cell.com
The mTOR-dependent nutrient-sensing and response machinery is the central hub for
animals to regulate their cellular and developmental programs. However, equivalently …