Chemical discovery in the era of metabolomics
M Sindelar, GJ Patti - Journal of the American Chemical Society, 2020 - ACS Publications
Untargeted metabolomics aims to quantify the complete set of metabolites within a biological
system, most commonly by liquid chromatography/mass spectrometry (LC/MS). Since nearly …
system, most commonly by liquid chromatography/mass spectrometry (LC/MS). Since nearly …
Starvation Responses Throughout the Caenorhabditis elegans Life Cycle
Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …
has a variety of adaptive responses to starvation. These features of its life history make the …
A neurotransmitter produced by gut bacteria modulates host sensory behaviour
Animals coexist in commensal, pathogenic or mutualistic relationships with complex
communities of diverse organisms, including microorganisms. Some bacteria produce …
communities of diverse organisms, including microorganisms. Some bacteria produce …
Chemosensory signal transduction in Caenorhabditis elegans
DM Ferkey, P Sengupta, ND L'Etoile - Genetics, 2021 - academic.oup.com
Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …
tastants, and pheromones, into information that drives attraction or avoidance motor …
Balancing selection shapes density-dependent foraging behaviour
The optimal foraging strategy in a given environment depends on the number of competing
individuals and their behavioural strategies. Little is known about the genes and neural …
individuals and their behavioural strategies. Little is known about the genes and neural …
Parallel pathways for serotonin biosynthesis and metabolism in C. elegans
The neurotransmitter serotonin plays a central role in animal behavior and physiology, and
many of its functions are regulated via evolutionarily conserved biosynthesis and …
many of its functions are regulated via evolutionarily conserved biosynthesis and …
C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues
For sexually reproducing animals, selecting optimal mates is important for maximizing
reproductive fitness. In the nematode C. elegans, populations reproduce largely by …
reproductive fitness. In the nematode C. elegans, populations reproduce largely by …
Regulation and modulation of biogenic amine neurotransmission in Drosophila and Caenorhabditis elegans
KD Rosikon, MC Bone, HO Lawal - Frontiers in Physiology, 2023 - frontiersin.org
Neurotransmitters are crucial for the relay of signals between neurons and their target.
Monoamine neurotransmitters dopamine (DA), serotonin (5-HT), and histamine are found in …
Monoamine neurotransmitters dopamine (DA), serotonin (5-HT), and histamine are found in …
Mass spectrometric evaluation of mephedrone in vivo human metabolism: identification of phase I and phase II metabolites, including a novel succinyl conjugate
In recent years, many new designer drugs have emerged, including the group of cathinone
derivatives. One frequently occurring drug is mephedrone; although mephedrone was …
derivatives. One frequently occurring drug is mephedrone; although mephedrone was …
A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk
N Li, B Hua, Q Chen, F Teng, M Ruan, M Zhu, L Zhang… - Cell reports, 2022 - cell.com
The mTOR-dependent nutrient-sensing and response machinery is the central hub for
animals to regulate their cellular and developmental programs. However, equivalently …
animals to regulate their cellular and developmental programs. However, equivalently …