The influence of endothelial metabolic reprogramming on the tumor microenvironment

K Kane, D Edwards, J Chen - Oncogene, 2024 - nature.com
Endothelial cells (ECs) that line blood vessels act as gatekeepers and shape the metabolic
environment of every organ system. In normal conditions, endothelial cells are relatively …

Intracellular endothelial cell metabolism in vascular function and dysfunction

KM Citrin, B Chaube, C Fernández-Hernando… - Trends in Endocrinology …, 2024 - cell.com
Endothelial cells (ECs) form the inner lining of blood vessels that is crucial for vascular
function and homeostasis. They regulate vascular tone, oxidative stress, and permeability …

Bone-protective effects of neutralizing angiopoietin-like protein 4 monoclonal antibody in rheumatoid arthritis

L Ke, Q He, J Qu, X Wang, K Li, X Gong, L Li, J Xu… - Molecular Therapy, 2024 - cell.com
Despite recent advances, rheumatoid arthritis (RA) patients remain refractory to therapy.
Dysregulated overproduction of angiopoietin-like protein 4 (ANGPTL4) is thought to …

UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment

Y Li, M Jiang, L Aye, L Luo, Y Zhang, F Xu… - Nature …, 2024 - nature.com
The complexity of the tumor microenvironment (TME) is a crucial factor in lung
adenocarcinoma (LUAD) progression. To gain deeper insights into molecular mechanisms …

ANGPTL4 suppresses clear cell renal cell carcinoma via inhibition of lysosomal acid lipase

Z Jin, U De, TI Tithi, J Kleberg, A Nataraj… - Cancer research …, 2024 - aacrjournals.org
Renal cell carcinoma (RCC), the most common form of kidney cancer, is a heterogeneous
disease with clear cell RCC (ccRCC) being the most prevalent and aggressive subtype …

Characterization of sexual dimorphism in ANGPTL4 levels and function

M Deng, S Kersten - Journal of Lipid Research, 2024 - ASBMB
ANGPTL4 is an attractive pharmacological target for lowering plasma triglycerides and
cardiovascular risk. Since most preclinical studies on ANGPTL4 were performed in male …

[HTML][HTML] Advancing the clinical assessment of glomerular podocyte pathology in kidney biopsies via super-resolution microscopy and angiopoietin-like 4 staining

X Liu, S Wang, G Liu, Y Wang, S Shang, G Zou… - …, 2025 - pmc.ncbi.nlm.nih.gov
Rationale: The tertiary structure of normal podocytes prevents protein from leaking into the
urine. However, observing the complexity of podocytes is challenging because of the scale …

A new perspective on prostate cancer treatment: the interplay between cellular senescence and treatment resistance

MY Xu, ZY Xia, JX Sun, CQ Liu, Y An, JZ Xu… - Frontiers in …, 2024 - frontiersin.org
The emergence of resistance to prostate cancer (PCa) treatment, particularly to androgen
deprivation therapy (ADT), has posed a significant challenge in the field of PCa …

The loach haplotype-resolved genome and the identification of Mex3a involved in fish air breathing

B Sun, Q Li, X Xiao, J Zhang, Y Zhou, Y Huang, J Gao… - Cell Genomics, 2024 - cell.com
Fish air breathing is crucial for the transition of vertebrates from water to land. So far, the
genes involved in fish air breathing have not been well identified. Here, we performed gene …

iPSC-derived megakaryocytes and platelets accelerate wound healing and angiogenesis

K Kosaka, N Takayama, SK Paul, MA Kanashiro… - Stem Cell Research & …, 2024 - Springer
Background Platelet-rich plasma (PRP), which is prepared by concentrating platelets in
autologous blood, shows efficacy in chronic skin wounds via multiple growth factors …