YAP/TAZ at the roots of cancer
F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
Gastric adenocarcinoma
JA Ajani, J Lee, T Sano, YY Janjigian, D Fan… - Nature reviews Disease …, 2017 - nature.com
Gastric cancers, with gastric adenocarcinoma (GAC) as the most common histological type,
impose a considerable global health burden. Although the screening strategies for early …
impose a considerable global health burden. Although the screening strategies for early …
Analysis of the role of the Hippo pathway in cancer
Y Han - Journal of translational medicine, 2019 - Springer
Cancer is a serious health issue in the world due to a large body of cancer-related human
deaths, and there is no current treatment available to efficiently treat the disease as the …
deaths, and there is no current treatment available to efficiently treat the disease as the …
Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by
Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC …
Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC …
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain
JM Lamar, P Stern, H Liu… - Proceedings of the …, 2012 - National Acad Sciences
The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ
size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue …
size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue …
Streptococcus thermophilus inhibits colorectal tumorigenesis through secreting β-galactosidase
Background & Aims Streptococcus thermophilus was identified to be depleted in patients
with colorectal cancer (CRC) by shotgun metagenomic sequencing of 526 multicohort fecal …
with colorectal cancer (CRC) by shotgun metagenomic sequencing of 526 multicohort fecal …
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates
and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a …
and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a …
The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression
The Hippo signaling pathway controls organ size and tumorigenesis through a kinase
cascade that inactivates Yes‐associated protein (YAP). Here, we show that YAP plays a …
cascade that inactivates Yes‐associated protein (YAP). Here, we show that YAP plays a …
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer
In many cancers, tumour progression is associated with increased tissue stiffness. Yet, the
mechanisms associating tissue stiffness with tumorigenesis and malignant transformation …
mechanisms associating tissue stiffness with tumorigenesis and malignant transformation …
[HTML][HTML] Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells
Background Gastric cancer (GC) is one of the most common cancer worldwide. We analyzed
the expression of m 6 A regulatory genes in GC cohorts and revealed that YTHDF1 was …
the expression of m 6 A regulatory genes in GC cohorts and revealed that YTHDF1 was …