Visualizing GABA transporters in vivo: an overview of reported radioligands and future directions

N Knippenberg, M Bauwens, O Schijns, G Hoogland… - EJNMMI research, 2023 - Springer
By clearing GABA from the synaptic cleft, GABA transporters (GATs) play an essential role in
inhibitory neurotransmission. Consequently, in vivo visualization of GATs can be a valuable …

Paradigms and Success Stories of Natural Products in Drug Discovery Against Neurodegenerative Disorders (NDDs)

S Singh, S Chib, MJ Akhtar, B Kumar… - Current …, 2024 - ingentaconnect.com
Neurodegenerative disorders (NDDs) are multifaceted complex disorders that have put a
great health and economic burden around the globe nowadays. The multi-factorial nature of …

A multi-faceted approach to unravel coding and non-coding gene fusions and target chimeric proteins in ataxia

O Gullulu, E Ozcelik, M Tuzlakoglu Ozturk… - Journal of …, 2024 - Taylor & Francis
Ataxia represents a heterogeneous group of neurodegenerative disorders characterized by
a loss of balance and coordination, often resulting from mutations in genes vital for …

Solvent‐Free Synthesis of Quaternary Oxazolidine‐2‐thione β3‐Amino Ester Analogs

F Soddu, F Devoto, V Marras, P Caboni… - European Journal of …, 2022 - Wiley Online Library
A solvent‐free organocatalyzed intermolecular cyclization reaction starting from β‐
substituted γ‐hydroxy‐α, β‐unsaturated esters and aryl isothiocyanates proceeds via an aza …

Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid

FM Garofalo, ML Sbaraglini… - Future Medicinal …, 2023 - Taylor & Francis
Background: New hybrid compounds were synthesized by linking the valproic acid (VPA)
structure with other anticonvulsant/anti-inflammatory scaffolds. Materials & methods: The …