Our understanding of the genetics of acute myeloid leukemia (AML) development from
myelodysplastic syndrome (MDS) has advanced significantly as a result of next-generation …

Thrombopoietin (TPO) is the primary hematopoietic growth let counts, the cells of the
proximal convoluted tubules of factor involved in the regulation of platelet production. Al- the …

Bone marrow CD34+ cell apoptosis (annexin V), proliferation (Ki-67), and Bcl-2-related
protein expression was evaluated by flow cytometry in 102 patients with myelodysplastic …

Multipotential hematopoietic progenitor cell lines have been established from nonadherent
cell populations removed from continuous mouse bone marrow cultures. Clonal sublines of …

Abstract Divalent metal transporter 1 (DMT1) is a transmembrane protein crucial for
duodenal iron absorption and erythroid iron transport. DMT1 function has been elucidated …

Restriction fragment length polymorphisms (RFLPs) of the X-chromosome genes
hypoxanthine phosphoribosyl transferase (HPRT) and phosphoglycerate kinase (PGK) were …

The immunoglobulin levels and autoantibody profiles of 104 patients with primary
myelodysplastic syndromes (MDS), classified according to the FAB criteria, were analysed …

Thrombosis is a major cause of morbidity and mortality in polycythemia vera (PV) and
essential thrombocythemia (ET). The pathophysiology of thrombosis in these disorders …

(CFU-M). 5 Erythroid burst-forming units (BFU-E) 6 represent earlier erythroid progenitors
than CFU-E. Progenitors assayable in these clonal cultures represent a continuum of stages …

Modelling the genesis of human cancers is at a scientific turning point. Starting from primary
sources of normal human cells, it is now possible to reproducibly generate several types of …