Conspectus Carbon monoxide (CO) is a gaseous signaling molecule produced in humans
via the breakdown of heme in an O2-dependent reaction catalyzed by heme oxygenase …

Every cell has a highly sophisticated system for regulating heme levels, which is particularly
important with regard to turnover. Heme degradation generates CO and while CO has long …

Carbon monoxide (CO) has long been considered a toxic gas but is now a recognized
bioactive gasotransmitter with potent immunomodulatory effects. Although inhaled CO is …

Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …

The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …

Gaseous molecules have been increasingly explored for therapeutic development. Here,
following an analytical background introduction, a systematic review of medical gas …

Heme oxygenase-1 (HO-1) is an inducible stress protein that catalyzes the oxidative
conversion of heme to carbon monoxide (CO), iron, and biliverdin (BV), the latter of which is …

It is estimated that 10% of carbon throughout the cosmos is in the form of carbon monoxide
(CO). Earth's earliest prebiotic atmosphere included the trinity of gasotransmitters CO, nitric …

Nature has endowed gaseous molecules such as O 2, CO 2, CO, NO, H 2 S, and N 2 with
critical and diverse roles in sustaining life, from supplying energy needed to power life and …

Carbon monoxide (CO) is not only known as a toxic gas due to its characteristics as an
odorless molecule and its rapid binding to haem-containing molecules, thus inhibiting the …