Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

We report a systematic review and meta-analysis of studies that assessed the
antinociceptive efficacy of cannabinoids, cannabis-based medicines, and endocannabinoid …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

The President of the International Association for the Study of Pain established a task force
on cannabis and cannabinoid analgesia to systematically examine the evidence on (1) …

Large variability in the individual response to even the most-efficacious pain treatments is
observed clinically, which has led to calls for a more personalized, tailored approach to …

Spontaneous pain, a major complaint of patients with neuropathic pain, has eluded study
because there is no reliable marker in either preclinical models or clinical studies. Here, we …

Chronic pain is a complex and challenging medical condition that affects millions of people
worldwide. Understanding the underlying mechanisms of chronic pain is a key goal of …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …