System Xc /GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

FJ Li, HZ Long, ZW Zhou, HY Luo, SG Xu… - Frontiers in …, 2022 - frontiersin.org
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

Ferroptosis and its role in chronic diseases

W Hu, K Liang, H Zhu, C Zhao, H Hu, S Yin - Cells, 2022 - mdpi.com
Ferroptosis, which has been widely associated with many diseases, is an iron-dependent
regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits …

Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy

N Xing, Q Du, S Guo, G Xiang, Y Zhang, X Meng… - Cell Death …, 2023 - nature.com
Lung cancer is a common malignant tumor that occurs in the human body and poses a
serious threat to human health and quality of life. The existing treatment methods mainly …

Ferroptosis in non-small cell lung cancer: progression and therapeutic potential on it

J Zou, L Wang, H Tang, X Liu, F Peng… - International Journal of …, 2021 - mdpi.com
As a main subtype of lung cancer, the current situation of non-small cell lung cancer
(NSCLC) remains severe worldwide with a 19% survival rate at 5 years. As the conventional …

Artesunate inhibits the cell growth in colorectal cancer by promoting ROS-dependent cell senescence and autophagy

Z Huang, S Gan, X Zhuang, Y Chen, L Lu, Y Wang… - Cells, 2022 - mdpi.com
Although artesunate has been reported to be a promising candidate for colorectal cancer
(CRC) treatment, the underlying mechanisms and molecular targets of artesunate are yet to …

[HTML][HTML] Medicinal and mechanistic overview of artemisinin in the treatment of human diseases

AM Posadino, R Giordo, G Pintus… - Biomedicine & …, 2023 - Elsevier
Artemisinin (ART) is a bioactive compound isolated from the plant Artemisia annua and has
been traditionally used to treat conditions such as malaria, cancer, viral infections, bacterial …

Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy

S Li, A Wang, Y Wu, S He, W Shuai… - Immunological …, 2024 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …

Regulated cell death in cancer: from pathogenesis to treatment

L Gong, D Huang, Y Shi, Z Liang, H Bu - Chinese Medical Journal, 2023 - mednexus.org
Regulated cell death (RCD), including apoptosis, pyroptosis, necroptosis, and ferroptosis, is
regulated by a series of evolutionarily conserved pathways, and is required for development …

[HTML][HTML] Artesunate: A review of its therapeutic insights in respiratory diseases

J Zhang, Y Li, J Wan, M Zhang, C Li, J Lin - Phytomedicine, 2022 - Elsevier
Background Artesunate, as a semi-synthetic artemisinin derivative of sesquiterpene lactone,
is widely used in clinical antimalarial treatment due to its endoperoxide group. Recent …

Lycopene alleviates multiple-mycotoxin-induced toxicity by inhibiting mitochondrial damage and ferroptosis in the mouse jejunum

J Lin, C Zuo, T Liang, Y Huang, P Kang, K Xiao… - Food & Function, 2022 - pubs.rsc.org
Multiple mycotoxins contamination in foods and feeds threatens human and animal health
after they accumulate in the food chain, producing various toxic effects. The common …