Early adolescent substance use dramatically increases the risk of lifelong substance use
disorder (SUD). An adolescent sensitive period evolved to allow the development of risk …

Adolescence encompasses a sensitive developmental period of enhanced clinical
vulnerability to nicotine, tobacco, and e‐cigarettes. While there are sociocultural influences …

Adolescence is a time of major plasticity of brain systems that regulate motivated behavior
and cognition, and is also the age of peak onset of nicotine use. Although there has been a …

Developmental periods such as gestation and adolescence have enhanced plasticity
leaving the brain vulnerable to harmful effects from nicotine use. Proper brain maturation …

There are two key alcohol use patterns among human adolescents that confer increased
vulnerability for later alcohol abuse/dependence, along with neurocognitive alterations:(a) …

Nicotinic acetylcholine receptors (nAChRs) regulate critical aspects of brain maturation
during the prenatal, early postnatal, and adolescent periods. During these developmental …

Epidemiological research has emphasized that adolescence is associated with some
temperamental and behavioral traits that are typical of this age and that might substantially …

Given the rise in teenage use of electronic nicotine delivery systems (“vaping”) in
congruence with the increasing numbers of drug-related emergencies, it is critical to expand …

BACKGROUND: Early substance use (SU) in adolescence is known to be associated with
an elevated risk of developing substance use disorders (SUD); it remains unclear though …

Cigarette smoking is often initiated during adolescence and an earlier age of onset is
associated with worse health outcomes later in life. Paradoxically, the transition towards …