[HTML][HTML] Understanding rotavirus vaccine efficacy and effectiveness in countries with high child mortality

T Varghese, G Kang, AD Steele - Vaccines, 2022 - mdpi.com
Rotavirus claims thousands of lives of children globally every year with a disproportionately
high burden in low-and lower-middle income countries where access to health care is …

Genetic heterogeneity of group A rotaviruses: a review of the evolutionary dynamics and implication on vaccination

CA Omatola, AO Olaniran - Expert Review of Anti-infective Therapy, 2022 - Taylor & Francis
Introduction Human rotavirus remains a major etiology of acute gastroenteritis among under
5-year children worldwide despite the availability of oral vaccines. The genetic instability of …

[HTML][HTML] The efficacy and safety of rotavirus vaccines in countries in Africa and Asia with high child mortality

N Henschke, H Bergman, D Hungerford, NA Cunliffe… - Vaccine, 2022 - Elsevier
Rotavirus remains a leading cause of diarrhoeal morbidity and mortality in young children
and rotavirus vaccines are critical for reducing global disease burden. This report addresses …

[HTML][HTML] mRNA-based VP8* nanoparticle vaccines against rotavirus are highly immunogenic in rodents

S Roier, V Mangala Prasad, MM McNeal, KK Lee… - npj Vaccines, 2023 - nature.com
Despite the availability of live-attenuated oral vaccines, rotavirus remains a major cause of
severe childhood diarrhea worldwide. Due to the growing demand for parenteral rotavirus …

Using species a rotavirus reverse genetics to engineer chimeric viruses expressing SARS-CoV-2 spike epitopes

O Diebold, V Gonzalez, L Venditti, C Sharp… - Journal of …, 2022 - Am Soc Microbiol
Species A rotavirus (RVA) vaccines based on live attenuated viruses are used worldwide in
humans. The recent establishment of a reverse genetics system for rotoviruses (RVs) has …

[HTML][HTML] Whole-genome characterization of common rotavirus strains circulating in Vellore, India from 2002 to 2017: emergence of non-classical genomic …

SA Khakha, T Varghese, S Giri, A Durbin, GS Tan… - Gut Pathogens, 2023 - Springer
Rotaviruses (RVs) are the most common etiological agent of acute gastroenteritis among
young children, even after vaccine introduction in low-income countries. A whole-genome …

[HTML][HTML] The value of rotavirus vaccination in Europe: a call for action

R Cohen, F Martinón-Torres, I Posiuniene… - Infectious Diseases and …, 2023 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has pushed
many healthcare systems into crisis. High vaccine coverage amongst children reduces …

[HTML][HTML] Rotavirus VP6: involvement in immunogenicity, adjuvant activity, and use as a vector for heterologous peptides, drug delivery, and production of nano …

Z Shoja, S Jalilvand, T Latifi, F Roohvand - Archives of Virology, 2022 - Springer
The first-generation, live attenuated rotavirus (RV) vaccines, such as RotaTeq and Rotarix,
were successful in reducing the number of RV-induced acute gastroenteritis (AGE) and child …

Generation of recombinant rotaviruses expressing human norovirus capsid proteins

AA Philip, JT Patton - Journal of Virology, 2022 - Am Soc Microbiol
Rotavirus, a segmented double-stranded RNA virus of the Reoviridae family, is a primary
cause of acute gastroenteritis in young children. In countries where rotavirus vaccines are …

[HTML][HTML] Genomic and evolutionary characteristics of G9P [8], the dominant group a rotavirus in China (2016–2018)

X Liu, M Wang, S Li, J Li, J Xiao, H Li, Q Zhang… - Frontiers in …, 2022 - frontiersin.org
G9P [8] became the predominant rotavirus A (RVA) genotype in China in 2012. To evaluate
its genetic composition at the whole-genome level, 115 G9P [8] RVA strains isolated from …