Snoopy–a unifying Petri net tool

M Heiner, M Herajy, F Liu, C Rohr… - Application and Theory of …, 2012 - Springer
The tool Snoopy provides a unifying Petri net framework which has particularly many
application scenarios in systems and synthetic biology. The framework consists of two …

Coloured Petri nets for multilevel, multiscale and multidimensional modelling of biological systems

F Liu, M Heiner, D Gilbert - Briefings in bioinformatics, 2019 - academic.oup.com
Owing to the availability of data of one biological phenomenon at different levels/scales,
modelling of biological systems is moving from single level/scale to multiple levels/scales …

Efficient unfolding of coloured Petri nets using interval decision diagrams

M Schwarick, C Rohr, F Liu, G Assaf, J Chodak… - Application and Theory …, 2020 - Springer
We consider coloured Petri nets, qualitative and quantitative ones alike, as supported by our
PetriNuts tool family, comprising, among others, Snoopy, Marcie and Spike. Currently, most …

[HTML][HTML] Coloured fuzzy Petri nets for modelling and analysing membrane systems

G Assaf, M Heiner, F Liu - Biosystems, 2022 - Elsevier
Membrane systems are a very powerful computational modelling formalism inspired by the
internal organisation of living cells. Modelling of membrane systems is challenged by …

Colouring space-a coloured framework for spatial modelling in systems biology

D Gilbert, M Heiner, F Liu, N Saunders - … and Theory of Petri Nets and …, 2013 - Springer
In this paper we introduce a technique to encode spatial attributes of dynamic systems using
coloured Petri nets and show how it can be applied to biological systems within the spirit of …

Spatial quorum sensing modelling using coloured hybrid Petri nets and simulative model checking

D Gilbert, M Heiner, L Ghanbar, J Chodak - BMC bioinformatics, 2019 - Springer
Background Quorum sensing drives biofilm formation in bacteria in order to ensure that
biofilm formation only occurs when colonies are of a sufficient size and density. This spatial …

Multiscale modeling and analysis of planar cell polarity in the Drosophila wing

Q Gao, D Gilbert, M Heiner, F Liu… - IEEE/ACM …, 2012 - ieeexplore.ieee.org
Modeling across multiple scales is a current challenge in Systems Biology, especially when
applied to multicellular organisms. In this paper, we present an approach to model at …

Petri nets for modeling and analyzing biochemical reaction networks

F Liu, M Heiner - Approaches in Integrative Bioinformatics: Towards the …, 2014 - Springer
Petri nets have been widely used to model and analyze biochemical reaction networks. This
chapter gives an overview of different types of Petri nets within a unifying Petri net framework …

Coloured Hybrid Petri Nets: An adaptable modelling approach for multi-scale biological networks

M Herajy, F Liu, C Rohr, M Heiner - Computational Biology and Chemistry, 2018 - Elsevier
Coloured Petri nets are an excellent choice for exploring large biological models,
particularly when there are repetitions of components. Such models can be easily adapted …

Modeling membrane systems using colored stochastic Petri nets

F Liu, M Heiner - Natural Computing, 2013 - Springer
Membrane systems are a very powerful computational modeling language inspired by the
internal organization of living cells. In this paper we explore the use of colored stochastic …