Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models
D Ezhilarasan - Environmental Toxicology and Pharmacology, 2023 - Elsevier
Thioacetamide (TAA) undergoes bioactivation in the liver by the CYP450 2E1 enzyme,
resulting in the formation of TAA-S-oxide and TAA-S-dioxide. TAA-S-dioxide induces …
resulting in the formation of TAA-S-oxide and TAA-S-dioxide. TAA-S-dioxide induces …
Connection between radiation-regulating functions of natural products and miRNAs targeting radiomodulation and exosome biogenesis
JY Tang, YT Chuang, JP Shiau, CY Yen… - International journal of …, 2023 - mdpi.com
Exosomes are cell-derived membranous structures primarily involved in the delivery of the
payload to the recipient cells, and they play central roles in carcinogenesis and metastasis …
payload to the recipient cells, and they play central roles in carcinogenesis and metastasis …
Efficacy of curcumin plus piperine co‐supplementation in moderate‐to‐high hepatic steatosis: a double‐blind, randomized, placebo‐controlled clinical trial
S Sharifi, M Bagherniya, Z Khoram… - Phytotherapy …, 2023 - Wiley Online Library
Abstract Non‐alcoholic Fatty Liver Disease (NAFLD) is a global health problem that can
progress to steatohepatitis and cirrhosis. The aim of this study was to determine the effect of …
progress to steatohepatitis and cirrhosis. The aim of this study was to determine the effect of …
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: Based on transcriptomics and …
Y Huang, W Luo, S Chen, H Su, W Zhu, Y Wei, Y Qiu… - Phytomedicine, 2023 - Elsevier
Background Effective drugs for the treatment of hepatic fibrosis have not yet been identified.
Isovitexin (IVT) is a promising hepatoprotective agent owing to its efficacy against acute liver …
Isovitexin (IVT) is a promising hepatoprotective agent owing to its efficacy against acute liver …
GC–MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive …
The present study attempted to scrutinize the protective effect of the methanolic extract of P.
chaba stem bark against paracetamol-induced hepatotoxicity in Sprague− Dawley rats …
chaba stem bark against paracetamol-induced hepatotoxicity in Sprague− Dawley rats …
Regulation of NS5B Polymerase Activity of Hepatitis C Virus by Target Specific Phytotherapeutics: An In-Silico Molecular Dynamics Approach
S Dhanasekaran, PP Selvadoss… - Cell Biochemistry and …, 2024 - Springer
Chronic hepatitis caused by the hepatitis C virus (HCV) is closely linked with the
advancement of liver disease. The research hypothesis suggests that the NS5B enzyme …
advancement of liver disease. The research hypothesis suggests that the NS5B enzyme …
Myosin heavy chain as a novel key modulator of striated muscle resting state
After years of intense research using structural, biological, and biochemical experimental
procedures, it is clear that myosin molecules are essential for striated muscle contraction …
procedures, it is clear that myosin molecules are essential for striated muscle contraction …
The impact of piperine on the metabolic conditions of patients with NAFLD and early cirrhosis: a randomized double-blind controlled trial
M Nouri-Vaskeh, P Hashemi, N Hataminia… - Scientific Reports, 2024 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is a metabolic dysfunction of the liver defined as
an abnormal accumulation of fat within the liver without secondary triggers like alcohol …
an abnormal accumulation of fat within the liver without secondary triggers like alcohol …
Research progress regarding the effect and mechanism of dietary polyphenols in liver fibrosis
J Chang, C Huang, S Li, X Jiang, H Chang, M Li - Molecules, 2023 - mdpi.com
The development of liver fibrosis is a result of chronic liver injuries may progress to liver
cirrhosis and liver cancer. In recent years, liver fibrosis has become a major global problem …
cirrhosis and liver cancer. In recent years, liver fibrosis has become a major global problem …
Altered hallmarks of DNA double-strand breaks, oxidative DNA damage and cytogenotoxicity by piperlongumine in hippocampus and hepatocytes of rats intoxicated …
Aim Cyclophosphamide is an effective anti-tumor agent, however, it induces genomic
instability and tissue toxicity in clinical application. This study aims to evaluate the action of …
instability and tissue toxicity in clinical application. This study aims to evaluate the action of …