Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's …

MA Daulatzai - Journal of neuroscience research, 2017 - Wiley Online Library
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Disentangling the role of astrocytes in alcohol use disorder

L Adermark, MS Bowers - Alcoholism: Clinical and …, 2016 - Wiley Online Library
Several laboratories recently identified that astrocytes are critical regulators of addiction
machinery. It is now known that astrocyte pathology is a common feature of ethanol (EtOH) …

Molecular neuropathology of astrocytes and oligodendrocytes in alcohol use disorders

JJ Miguel-Hidalgo - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Postmortem studies reveal structural and molecular alterations of astrocytes and
oligodendrocytes in both the gray and white matter (GM and WM) of the prefrontal cortex …

Neuroprotective Effects of Pre-Treament with l-Carnitine and Acetyl-l-Carnitine on Ischemic Injury In Vivo and In Vitro

R Zhang, H Zhang, Z Zhang, T Wang, J Niu… - International journal of …, 2012 - mdpi.com
The therapeutic effect of stroke is hampered by the lack of neuroprotective drugs against
ischemic insults beyond the acute phase. Carnitine plays important roles in mitochondrial …

Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation

M Kreft, LK Bak, HS Waagepetersen… - ASN neuro, 2012 - journals.sagepub.com
Astrocytes are key players in brain function; they are intimately involved in neuronal
signalling processes and their metabolism is tightly coupled to that of neurons. In the present …

Osmotic demyelination syndrome: novel risk factors and proposed pathophysiology

R Ambati, LK Kho, D Prentice… - Internal medicine …, 2023 - Wiley Online Library
Background Osmotic demyelination syndrome (ODS) is non‐inflammatory demyelination in
response to an osmotic challenge. It can be pontine or extrapontine in presentation. Aims To …

Low glucose utilization and neurodegenerative changes caused by sodium fluoride exposure in rat's developmental brain

C Jiang, S Zhang, H Liu, Z Guan, Q Zeng… - Neuromolecular …, 2014 - Springer
Fluorine, a toxic and reactive element, is widely prevalent throughout the environment and
can induce toxicity when absorbed into the body. This study was to explore the possible …

Caffeic acid phenethyl ester (CAPE) protects PC12 cells against cisplatin-induced neurotoxicity by activating the AMPK/SIRT1, MAPK/Erk, and PI3k/Akt signaling …

RS Ferreira, NAG Dos Santos, CP Bernardes… - Neurotoxicity …, 2019 - Springer
Peripheral sensory neuropathy (PSN) is a well-known side effect of cisplatin characterized
by axonal damage. In the early stage of neurotoxicity, cisplatin affects proteins that modulate …

A single‐nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens

EJCG van den Oord, LY Xie, M Zhao… - Addiction …, 2023 - Wiley Online Library
Gene expression studies offer promising opportunities to better understand the processes
underlying alcohol use disorder (AUD). As cell types differ in their function, gene expression …

Neuropathology of alcoholism

GT Sutherland, D Sheedy, JJ Kril - Handbook of clinical neurology, 2014 - Elsevier
Chronic alcohol consumption results in structural changes to the brain. In alcoholics without
coexisting thiamine deficiency or liver disease this is largely restricted to a loss of white …