Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Cilia are ubiquitous microtubule-based eukaryotic organelles that project from the cell to
generate motility or function in cellular signaling. Motile cilia or flagella contain axonemal …

Cross-linking mass spectrometry has become an established technology to provide
structural information on the topology and dynamics of protein complexes. Readily …

Intraflagellar transport (IFT) is a highly conserved mechanism for motor-driven transport of
cargo within cilia, but how this cargo is selectively transported to cilia is unclear …

The intraflagellar transport (IFT) system is a remarkable molecular machine used by cells to
assemble and maintain the cilium, a long organelle extending from eukaryotic cells that …

Bardet-Biedl syndrome (BBS) is a currently incurable ciliopathy caused by the failure to
correctly establish or maintain cilia-dependent signaling pathways. Eight proteins …

Intraflagellar transport (IFT) sculpts the proteome of cilia and flagella; the antenna-like
organelles found on the surface of virtually all human cell types. By delivering proteins to the …

The BBSome is a heterooctameric protein complex that plays a central role in primary cilia
homeostasis. Its malfunction causes the severe ciliopathy Bardet-Biedl syndrome (BBS). The …

Cilia and flagella serve as cellular antennae and propellers in various eukaryotic cells, and
contain specific receptors and ion channels as well as components of axonemal …

The neuronal axon is packed with cytoskeletal filaments, membranes, and organelles, many
of which move between the cell body and axon tip. Here, we used cryo-electron tomography …