Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The
most common sites of metastasis are the liver and the peritoneum. Peritoneal …

Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall
prognosis that has remained virtually unchanged for many decades. Currently, prevention or …

Pancreatic cancer remains one of the most lethal of malignancies and a major health
burden. We performed whole-genome sequencing and copy number variation (CNV) …

The poor correlation of mutational landscapes with phenotypes limits our understanding of
the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we …

Just as reference genome sequences revolutionized human genetics, reference maps of
interactome networks will be critical to fully understand genotype-phenotype relationships …

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

The Hippo pathway has been implicated in suppressing tissue overgrowth and tumor
formation by restricting the oncogenic activity of YAP. However, transcriptional regulators …

Synonymous mutations change the sequence of a gene without directly altering the
sequence of the encoded protein. Here, we present evidence that these" silent" mutations …

F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …

Over the past decade, rapid advances in genomics, proteomics and functional genomics
technologies that enable in-depth interrogation of cancer genomes and proteomes and high …