Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …

Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that
convey communication from adipose tissue to other organs. Here, to delineate their role as …

Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in
contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that …

Multiple G protein-coupled receptors (GPCRs) are expressed in pancreatic islet cells, but the
majority have unknown functions. We observed specific GPCRs localized to primary cilia, a …

Pancreatic islets regulate glucose homeostasis through coordinated actions of hormone-
secreting cells. What underlies the function of the islet as a unit is the close approximation …

An emerging number of rare genetic disorders termed ciliopathies are associated with
pediatric obesity. It is becoming clear that the mechanisms associated with cilia dysfunction …

Diabetes-associated bone complications lead to fragile bone mechanical strength and
osteoporosis, aggravating the disease burden of patients. Advanced evidence shows that …

Aims Spatially-organized increases in cytosolic Ca 2+ within pancreatic beta cells in the
pancreatic islet underlie the stimulation of insulin secretion by high glucose. Recent data …

ABSTRACT GLI-Similar 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc
finger transcription factors that functions as an activator or repressor of gene expression …