Introduction During the last decades, the ever-increasing proportion of patients with cancer
has been led to serious concerns worldwide. Therefore, the development and use of novel …

Local acidification is a common feature of many disease processes such as inflammation,
infarction, or solid tumor growth. Acidic pH is not merely a sequela of disease but contributes …

The detection of H+ concentration variations in the extracellular milieu is accomplished by a
series of specialized and non-specialized pH-sensing mechanisms. The proton-activated G …

Intestinal strictures remain one of the most intractable and common complications of Crohn's
disease (CD). Approximately 70% of CD patients will develop fibrotic strictures after 10 years …

Head and neck cancer is the sixth most common malignancy, and there is an urgent need to
identify physiological processes contributing to tumorigenesis. Extracellular acidification …

Low pH in the gut is associated with severe inflammation, fibrosis, and colorectal cancer
(CRC) and is a hallmark of active inflammatory bowel disease (IBD). Subsequently, pH …

Inflammatory bowel disease (IBD) is characterized by chronic mucosal inflammation of the
gastrointestinal tract and is associated with extracellular acidification of mucosal tissue …

Simple Summary Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's
disease, is a debilitating condition with chronic inflammation in the digestive tract. Patients …

Introduction Intestinal fibrosis is a common complication of Inflammatory Bowel Disease
(IBD) with no available drugs. The current therapeutic principle is surgical intervention as the …

In steady state, intestinal subepithelial myofibroblasts form a thin layer below the basement
membrane. Unlike the rest of the stromal cells in the lamina propria, they express tensile …