The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

Various studies have shown that brain-derived neurotrophic factor (BDNF) increases
neuronal excitability and is localized and upregulated in areas implicated in …

A single exposure to cocaine rapidly induces the brief activation of several immediate early
genes, but the role of such short-term regulation in the enduring consequences of cocaine …

The high concentration of the tyrosine-rich polypeptide, neuropeptide Y (NPY), and the
increase in the number of its receptor subtypes that have been characterized in the brain …

Although the neuropathological changes caused by severe or repeated seizures have been
well characterized, many questions about the molecular mechanisms involved remain …

Mesio-temporal lobe epilepsy (MTLE), the most common drug-resistant epilepsy syndrome,
is characterized by the recurrence of spontaneous focal seizures after a latent period that …

Bcl-2 family gene products are critical to the integration of cell death stimuli that target the
mitochondrion. Proapoptotic BAD (Bcl-2-associated death protein) has been shown to …

The results of several studies have contributed to the hypothesis that BDNF promotes
seizure activity, particularly in adult hippocampus. To test this hypothesis, BDNF, vehicle …

It is clear that brain‐derived neurotrophic factor (BDNF) plays a crucial role in organizing the
response of the genome to dynamic changes in the extracellular environment that enable …