Hepatitis E virus genome structure and replication strategy
Hepatitis E virus (HEV) possesses many of the features of other positive-stranded RNA
viruses but also adds HEV-specific nuances, making its virus–host interactions unique. Slow …
viruses but also adds HEV-specific nuances, making its virus–host interactions unique. Slow …
[HTML][HTML] Hepatitis E virus replication
R LeDesma, I Nimgaonkar, A Ploss - Viruses, 2019 - mdpi.com
Hepatitis E virus (HEV) is a small quasi-enveloped,(+)-sense, single-stranded RNA virus
belonging to the Hepeviridae family. There are at least 20 million HEV infections annually …
belonging to the Hepeviridae family. There are at least 20 million HEV infections annually …
Viral macro domains reverse protein ADP-ribosylation
ABSTRACT ADP-ribosylation is a posttranslational protein modification in which ADP-ribose
is transferred from NAD+ to specific acceptors to regulate a wide variety of cellular …
is transferred from NAD+ to specific acceptors to regulate a wide variety of cellular …
[HTML][HTML] De novo modelling of HEV replication polyprotein: Five-domain breakdown and involvement of flexibility in functional regulation
S Fieulaine, T Tubiana, S Bressanelli - Virology, 2023 - Elsevier
Hepatitis E virus (HEV), a major cause of acute viral hepatitis, is a single-stranded, positive-
sense RNA virus. As such, it encodes a 1700-residue replication polyprotein pORF1 that …
sense RNA virus. As such, it encodes a 1700-residue replication polyprotein pORF1 that …
Two mutations in the ORF1 of genotype 1 hepatitis E virus enhance virus replication and may associate with fulminant hepatic failure
Hepatitis E virus (HEV) infection in pregnant women has a high incidence of developing
fulminant hepatic failure (FHF) with significant mortality. Multiple amino acid changes in …
fulminant hepatic failure (FHF) with significant mortality. Multiple amino acid changes in …
[HTML][HTML] Hepatitis E virus mutations: functional and clinical relevance
Hepatitis E virus (HEV) infection is a major cause of acute hepatitis and affects more than 20
million individuals, with three million symptomatic cases and 56,000 recognized HEV …
million individuals, with three million symptomatic cases and 56,000 recognized HEV …
[HTML][HTML] Hepatitis E and pregnancy: an unholy alliance unmasked from Kashmir, India
MS Khuroo - Viruses, 2021 - mdpi.com
The adverse relationship between viral hepatitis and pregnancy in developing countries had
been interpreted as a reflection of retrospectively biased hospital-based data collection by …
been interpreted as a reflection of retrospectively biased hospital-based data collection by …
[HTML][HTML] Structural aspects of hepatitis E virus
F Cancela, O Noceti, J Arbiza, S Mirazo - Archives of Virology, 2022 - Springer
Hepatitis E virus (HEV) is a leading cause of acute hepatitis worldwide. Hepatitis E is an
enterically transmitted zoonotic disease that causes large waterborne epidemic outbreaks in …
enterically transmitted zoonotic disease that causes large waterborne epidemic outbreaks in …
Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replication
Hepatitis E virus (HEV) is an RNA virus responsible for over 20 million infections annually.
HEV's open reading frame (ORF) 1 polyprotein is essential for genome replication, though it …
HEV's open reading frame (ORF) 1 polyprotein is essential for genome replication, though it …
[HTML][HTML] Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficiencies
PB Devhare, S Desai, KS Lole - Scientific reports, 2016 - nature.com
Hepatitis E virus (HEV) is a significant health problem in developing countries causing
sporadic and epidemic forms of acute viral hepatitis. Hepatitis E is a self-limiting disease; …
sporadic and epidemic forms of acute viral hepatitis. Hepatitis E is a self-limiting disease; …