Objective Physical activity (PA) is associated with a decreased incidence of dementia, but
much of the evidence comes from short follow-ups prone to reverse causation. This meta …

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

The operationalization of childhood trauma and adversity into checklists commonly known
as adverse childhood experiences, or ACEs, has become the most widely adopted …

Abstract Purpose of Review The article discusses the two most significant modifiable risk
factors for dementia, namely, physical inactivity and lack of stimulating cognitive activity, and …

Background: Several longitudinal studies found an inverse relationship between levels of
physical activity and cognitive decline, dementia, and/or Alzheimer's disease (AD), but …

Evidence suggests that lifelong cumulative exposure to pesticides may generate lasting
toxic effects on the central nervous system and contribute to the development of Alzheimer's …

A recent alarming rise of neurodegenerative diseases in the developed world is one of the
major medical issues affecting older adults. In this review, we provide information about the …

Background There is considerable evidence of the favourable role of more physical activity
(PA) in fighting against dementia. However, the shape of the dose–response relationship is …

Background and Objectives Leisure activities are major components of modifiable and
healthy lifestyles and are proposed to help prevent the development of dementia. This study …

Advances in genetic and genomic technologies over the last thirty years have greatly
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …