Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …

Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease
(NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically …

Acute psychological stress has long been known to decrease host fitness to inflammation in
a wide variety of diseases, but how this occurs is incompletely understood. Using mouse …

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs
and maintain an individual's health. The liver has a major role in the control of glucose …

Pregnane X receptor is a ligand-activated nuclear receptor (NR) that mainly controls
inducible expression of xenobiotics handling genes including biotransformation enzymes …

Zinc is an essential micronutrient for human health and is involved in various biological
functions, such as growth, metabolism, and immune function. In recent years, research on …

Impaired estrogens action is associated with features of the metabolic syndrome in animal
models and humans. We sought to determine whether disruption of hepatic estrogens action …

Lipid metabolism is a complex physiological process that is involved in nutrient adjustment,
hormone regulation, and homeostasis. An unhealthy lifestyle and chronic nutrient overload …

Quercetin and EGCG exhibit anti-diabetic and anti-obesity activities, however, their
interactive effects in anti-diabetic/anti-obesity actions and underlying mechanisms remain …