Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

J Baj, I Korona-Głowniak, A Forma, A Maani, E Sitarz… - Cells, 2020 - mdpi.com
Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of
the world's population. Approximately 20% of the infected patients develop gastric ulcers or …

Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori

M Suganuma, T Watanabe, K Yamaguchi, A Takahashi… - Cancer letters, 2012 - Elsevier
TNF-α-inducing protein (Tipα) is a unique carcinogenic factor of Helicobacter pylori, which is
secreted into culture broth. The biological activities of Tipα and deletion mutant were …

Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pyloriEast Asian genomes

M Kawai, Y Furuta, K Yahara, T Tsuru, K Oshima… - BMC microbiology, 2011 - Springer
Abstract Background The genome of Helicobacter pylori, an oncogenic bacterium in the
human stomach, rapidly evolves and shows wide geographical divergence. The high …

The TNF-Alpha Inducing Protein is Associated With Gastric Inflammation and Hyperplasia in a Murine Model of Helicobacter pylori Infection

L Morningstar-Wright, SJ Czinn, MB Piazuelo… - Frontiers in …, 2022 - frontiersin.org
Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the human
stomach leading to the development of chronic gastritis, peptic ulcers and gastric …

Role of TNF-α-Inducing Protein Secreted by Helicobacter pylori as a Tumor Promoter in Gastric Cancer and Emerging Preventive Strategies

M Suganuma, T Watanabe, E Sueoka, IK Lim, H Fujiki - Toxins, 2021 - mdpi.com
The tumor necrosis factor-α (TNF-α)-inducing protein (tipα) gene family, comprising
Helicobacter pylori membrane protein 1 (hp-mp1) and tipα, has been identified as a tumor …

Nucleolin as cell surface receptor for tumor necrosis factor-α inducing protein: a carcinogenic factor of Helicobacter pylori

T Watanabe, H Tsuge, T Imagawa, D Kise… - Journal of cancer …, 2010 - Springer
Purpose Tumor necrosis factor-α inducing protein (Tipα) is a unique carcinogenic factor
released from Helicobacter pylori (H. pylori). Tipα specifically binds to cells and is …

Identification of anti-Helicobacter pylori antibody signatures in gastric intestinal metaplasia

L Song, M Song, CS Rabkin, Y Chung… - Journal of …, 2023 - Springer
Abstract Background Chronic Helicobacter pylori infection may induce gastric intestinal
metaplasia (IM). We compared anti-H. pylori antibody profiles between IM cases and non …

[HTML][HTML] Structural and functional aspects of the Helicobacter pylori secretome

G Zanotti, L Cendron - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Proteins secreted by Helicobacter pylori (H. pylori), an important human pathogen
responsible for severe gastric diseases, are reviewed from the point of view of their …

Helicobacter pylori virulence factors: subversion of host immune system and development of various clinical outcomes

R Mohammadzadeh, S Menbari… - Expert Reviews in …, 2023 - cambridge.org
Helicobacter pylori (H. pylori) is a worldwide spread bacterium, co-evolving with humans for
at least 100 000 years. Despite the uncertainty about the mode of H. pylori transmission, the …

Host genetic factors respond to pathogenic step-specific virulence factors of Helicobacter pylori in gastric carcinogenesis

C He, M Chen, J Liu, Y Yuan - Mutation Research/Reviews in Mutation …, 2014 - Elsevier
The interindividual differences in risk of Helicobacter pylori (H. pylori)-associated gastric
cancer involve significant heterogeneities of both host genetics and H. pylori strains. Several …