Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands

A Iraji, M Khoshneviszadeh, O Firuzi… - Bioorganic …, 2020 - Elsevier
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …

Biosynthesis of zinc oxide nanoparticles using aqueous extract of Andrographis alata: Characterization, optimization and assessment of their antibacterial, antioxidant …

SS Dappula, YR Kandrakonda, JB Shaik… - Journal of Molecular …, 2023 - Elsevier
Recently, great attention was paid on the synthesis of nano particles via green protocols,
explicitly using plant materials. In view of this, currently, zinc oxide nano particles (ZnO NPs) …

Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis

D Lin, S Jiang, A Zhang, T Wu, Y Qian… - Natural Products and …, 2022 - Springer
Structural derivatization of natural products has been a continuing and irreplaceable source
of novel drug leads. Natural phenols are a broad category of natural products with wide …

In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives

MVK Reddy, KY Rao, G Anusha, GM Kumar… - Environmental …, 2021 - Elsevier
Cholinesterase enzymes such as acetylcholinesterase (AChE) and butyrylcholinesterase
(BuChE) cause hydrolysis of acetylcholine (ACh), a neurotransmitter responsible for the …

Inhibitory activities of flavonoids from Eupatorium adenophorum against acetylcholinesterase

M Li, X Gao, M Lan, X Liao, F Su, L Fan, Y Zhao… - Pesticide biochemistry …, 2020 - Elsevier
Fifteen flavonoids isolated from the Eupatorium adenophorum showed inhibitory activities
against acetylcholinesterase (AChE) isolated from Caenorhabditis elegans and Spodoptera …

Antioxidant compounds in the treatment of Alzheimer's disease: Natural, hybrid, and synthetic products

M Hatami, M Mortazavi, Z Baseri… - Evidence‐Based …, 2023 - Wiley Online Library
Alzheimer's disease (AD) which is associated with cognitive dysfunction and memory lapse
has become a health concern. Various targets and pathways have been involved in AD's …

Synthesis and anti-Alzheimer potential of novel α-amino phosphonate derivatives and probing their molecular interaction mechanism with acetylcholinesterase

KY Rao, SJ Basha, K Monika, M Sreelakshmi… - European Journal of …, 2023 - Elsevier
Pleiotropic interference may be a prerequisite for the efficient limitation of the progression of
multi-factorial diseases such as Alzheimer's disease (AD). Concept of designing the single …

Deciphering the AChE-binding mechanism with multifunctional tricyclic coumarin anti-Alzheimer's agents using biophysical and bioinformatics approaches and …

JB Shaik, YR Kandrakonda, M Kallubai… - International Journal of …, 2021 - Elsevier
Investigating the drug-AChE binding mechanism is vital in understanding its cogent use in
medical practice against Alzheimer's disease (AD). The production and accumulation of …

Development of quinazolinone and vanillin acrylamide hybrids as multi-target directed ligands against Alzheimer's disease and mechanistic insights into their binding …

K Yelamanda Rao, S Jeelan Basha… - Journal of …, 2023 - Taylor & Francis
Abstract In view of Multi-Target Directed Ligand (MTDL) approach in treating Alzheimer's
Disease (AD), a series of novel quinazolinone and vanillin cyanoacetamide based …

Synthesis, structural characterization and study of antioxidant and anti-PrPSc properties of flavonoids and their rhenium(I)–tricarbonyl complexes

P Glykofridi, VE Tziouri, K Xanthopoulos… - JBIC Journal of …, 2023 - Springer
This study aims at the synthesis and initial biological evaluation of novel rhenium–
tricarbonyl complexes of 3, 3′, 4′, 5, 7-pentahydroxyflavone (quercetin), 3, 7, 4΄ …