Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Emerging evidence from both clinical studies and animal models indicates the importance of
the interaction between the gut microbiome and the brain in the pathogenesis of …

Aim: Persistent activation of STING pathway is the basis for several autoimmune diseases.
STING is activated by cGAMP, which is produced by cGAS in the presence of DNA …

Halogenated 4-hydroxybenzylidene indolinones have been shown to re-sensitize methicillin-
resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis …

Various reports of multidrug-resistant bacteria that are immune to all available FDA-
approved drugs demand the development of novel chemical scaffolds as antibiotics. From …

The rise of antibiotic resistance, especially in Staphylococcus aureus, and the increasing
death rate due to multiresistant bacteria have been well documented. The need for new …

Abstract Cyclic dimeric adenosine 3′–5′-monophosphate (c-di-AMP) is a recently
discovered nucleotide messenger in bacteria. It plays an important role in signaling …

According to the Centers for Disease Control and Prevention (CDC), methicillin-resistant
Staphylococcus aureus (MRSA) affects about 80 000 patients in the US annually and …

The Centers for Disease Control and Prevention (CDC) recognizes Neisseria gonorrhoeae
as an urgent-threat Gram-negative bacterial pathogen. Additionally, resistance to frontline …

Cyclic di-AMP (c-di-AMP) is an essential secondary messenger regulating cell wall
homeostasis and myriads of physiological processes in several Gram-positive and …