Postoperative atrial fibrillation: mechanisms, manifestations and management

D Dobrev, M Aguilar, J Heijman, JB Guichard… - Nature Reviews …, 2019 - nature.com
Postoperative atrial fibrillation (POAF) complicates 20–40% of cardiac surgical procedures
and 10–20% of non-cardiac thoracic operations. Typical features include onset at 2–4 days …

Modernized classification of cardiac antiarrhythmic drugs

M Lei, L Wu, DA Terrar, CLH Huang - Circulation, 2018 - Am Heart Assoc
Background: Among his major cardiac electrophysiological contributions, Miles Vaughan
Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Atrial fibrillation pathophysiology: implications for management

Y Iwasaki, K Nishida, T Kato, S Nattel - Circulation, 2011 - Am Heart Assoc
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important
contributor to population morbidity and mortality. An arrhythmia that is particularly common …

Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

Recent advances in the molecular pathophysiology of atrial fibrillation

R Wakili, N Voigt, S Kääb, D Dobrev… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …

Mechanisms of atrial fibrillation

RS Wijesurendra, B Casadei - Heart, 2019 - heart.bmj.com
Atrial fibrillation (AF) is the most common sustained arrhythmia, currently affecting over 33
million individuals worldwide, and its prevalence is expected to more than double over the …

[HTML][HTML] The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox

D Moris, M Spartalis, E Spartalis… - Annals of …, 2017 - ncbi.nlm.nih.gov
Acute and chronic excessive intracellular increase of reactive oxygen species (ROS) is
involved in the development and progression of cardiovascular diseases. ROS are by …

Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation

E Grandi, SV Pandit, N Voigt, AJ Workman… - Circulation …, 2011 - Am Heart Assoc
Rationale: Understanding atrial fibrillation (AF) requires integrated understanding of ionic
currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited …

Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

HD Devalla, V Schwach, JW Ford, JT Milnes… - EMBO molecular …, 2015 - embopress.org
Drugs targeting atrial‐specific ion channels, Kv1. 5 or Kir3. 1/3.4, are being developed as
new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried …