[HTML][HTML] The role of epithelial cells in fibrosis: mechanisms and treatment
L Luo, W Zhang, S You, X Cui, H Tu, Q Yi, J Wu… - Pharmacological …, 2024 - Elsevier
Fibrosis is a pathological process that affects multiple organs and is considered one of the
major causes of morbidity and mortality in multiple diseases, resulting in an enormous …
major causes of morbidity and mortality in multiple diseases, resulting in an enormous …
The dichotomic role of single cytokines: Fine-tuning immune responses
RCMC Silva, LH Travassos, FF Dutra - Cytokine, 2024 - Elsevier
Cytokines are known for their pleiotropic effects. They can be classified by their function as
pro-inflammatory, such as tumor necrosis factor (TNF), interleukin (IL) 1 and IL-12, or anti …
pro-inflammatory, such as tumor necrosis factor (TNF), interleukin (IL) 1 and IL-12, or anti …
Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models
L Kong, S Chen, S Huang, A Zheng, S Gao, J Ye… - Inflammation …, 2024 - Springer
Background Inflammatory bowel disease (IBD) is an increasingly prevalent global health
concern that has garnered substantial attention. However, the underlying mechanisms are …
concern that has garnered substantial attention. However, the underlying mechanisms are …
Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease
E Urbauer, D Aguanno, N Mindermann, H Omer… - Cell Host & Microbe, 2024 - cell.com
Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBDs). To
understand how microbial-metabolic circuits contribute to intestinal injury, we disrupt …
understand how microbial-metabolic circuits contribute to intestinal injury, we disrupt …
[HTML][HTML] Exploring the potential of human intestinal organoids: Applications, challenges, and future directions
IA Parente, L Chiara, S Bertoni - Life Sciences, 2024 - Elsevier
The complex and dynamic environment of the gastrointestinal tract shapes one of the fastest
renewing tissues in the human body, the intestinal epithelium. Considering the lack of …
renewing tissues in the human body, the intestinal epithelium. Considering the lack of …
Tongxieyaofang Decotion Alleviates IBS by Modulating CHRM3 and Gut Barrier
T Feng, Y Zhou, B Lv, L Cai - Drug Design, Development and …, 2024 - Taylor & Francis
Purpose Through network pharmacology combined with molecular docking and in vivo
validation, the study examines the unexplored molecular mechanisms of Tongxieyaofang …
validation, the study examines the unexplored molecular mechanisms of Tongxieyaofang …
Control of intestinal stemness and cell lineage by histone variant H2A. Z isoforms
J Rispal, C Rives, V Jouffret, C Leoni… - … and Cellular Biology, 2024 - Taylor & Francis
The histone variant H2A. Z plays important functions in the regulation of gene expression. In
mammals, it is encoded by two genes, giving rise to two highly related isoforms named H2A …
mammals, it is encoded by two genes, giving rise to two highly related isoforms named H2A …
[HTML][HTML] Establishment of an in-vitro inflammatory bowel disease model using immunological differentiation of Caco-2 cells
I Uemura, N Takahashi-Suzuki, F Kita, T Satoh - MethodsX, 2024 - Elsevier
Studies on intestinal cell differentiation, particularly in dextran sodium sulfate (DSS)-induced
inflammatory bowel disease (IBD), have predominantly focused on the disruption of …
inflammatory bowel disease (IBD), have predominantly focused on the disruption of …
MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis
AJ Graham, MWL Khoo, V Srivastava, S Viragova… - bioRxiv, 2024 - biorxiv.org
Organoids are powerful models of tissue physiology, yet their applications remain limited
due to their relatively simple morphology and high organoid-to-organoid structural …
due to their relatively simple morphology and high organoid-to-organoid structural …