From the analysis of several studies published from 1979 to 1986 comprising 1,172 patients,
we estimated that glomerular filtration rate (GFR) was normal In 85% of unselected patients …

Despite the availability of alternative agents, lithium continues to be the standard against
which all mood stabilisers, prescribed for acute and maintenance treatment of bipolar (and …

Objectives: Safety monitoring is an important aspect of bipolar disorder treatment, as mood‐
stabilising medications have potentially serious side effects, some of which may also …

Discusses the relationship between depression and medical illness and the diagnosis and
management of depression in the medically ill. Covers methodological issues related to …

Reports of toxic effects on the kidney of lithium treatment emerged very soon after lithium
therapy was introduced. Lithium-induced nephrogenic diabetes insipidus is usually self …

Lithium treatment for 4 wk caused severe polyuria, dramatic downregulation in aquaporin-2
(AQP-2) expression, and marked decrease in AQP-2 immunoreactivity with the appearance …

Background: Lithium can cause nephrogenic diabetes insipidus in up to 20 to 40 percent of
patients currently taking the medication, and a subset of these patients will have a persistent …

Chronic renal failure (CRF) and nephrogenic diabetes insipidus (NDI) are potential
consequences of chronic lithium use, while acute renal failure (ARF) has been described in …

Side effects are among the most frequent reasons preventing patients from taking their
medication. Although the management of side effects is an important issue in clinical …

• Nephrogenic diabetes insipidus (NDI) is a frequent complication in patients receiving long-
term lithium therapy. Both thiazide diuretics and amiloride may reduce the polyuria, but the …