Targeting p53 pathways: mechanisms, structures, and advances in therapy
H Wang, M Guo, H Wei, Y Chen - Signal transduction and targeted …, 2023 - nature.com
The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …
been a major focus of oncology research. The p53 protein is a transcription factor that can …
p53 isoforms and their implications in cancer
M Vieler, S Sanyal - Cancers, 2018 - mdpi.com
In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …
Fundamentals of cross-seeding of amyloid proteins: an introduction
Misfolded protein aggregates formed by the same (homologous) or different
(heterologous/cross) sequences are the pathological hallmarks of many protein misfolding …
(heterologous/cross) sequences are the pathological hallmarks of many protein misfolding …
Therapeutic potential of p53 reactivation in prostate cancer: Strategies and opportunities
Metastatic prostate cancer (mCaP) remains one of the leading causes of cancer-related
death in men worldwide. Androgen receptor (AR) drives the progression of most of the …
death in men worldwide. Androgen receptor (AR) drives the progression of most of the …
Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds
The p53 family of proteins is comprised of p53, p63 and p73. Because the p53 DNA binding
domain (DBD) is naturally unstable and possesses an amyloidogenic sequence, it is prone …
domain (DBD) is naturally unstable and possesses an amyloidogenic sequence, it is prone …
Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC
Y Zhang, L Xu, Y Chang, YJ Li, W Butler, E Jin… - Prostate cancer and …, 2020 - nature.com
Backgrounds p53 is a tumor suppressor that prevents cancer onset and progression, and
mutations in the p53 gene cause loss of the tumor suppressor function of the protein. The …
mutations in the p53 gene cause loss of the tumor suppressor function of the protein. The …
Molecular understanding of Aβ-hIAPP cross-seeding assemblies on lipid membranes
Amyloid-β (Aβ) and human islet polypeptide (hIAPP) are the causative agents responsible
for Alzheimer's disease (AD) and type II diabetes (T2D), respectively. While numerous …
for Alzheimer's disease (AD) and type II diabetes (T2D), respectively. While numerous …
Common cancer mutations R175H and R273H drive the p53 DNA-binding domain towards aggregation-prone conformations
The p53 protein is a tumor suppressor and the most often mutated protein in human cancers.
Recent studies reported that p53 mutants, including two of the common cancer mutants …
Recent studies reported that p53 mutants, including two of the common cancer mutants …
Unraveling the influence of K280 acetylation on the conformational features of tau core fragment: a molecular dynamics simulation study
Y Zou, L Guan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Abnormal aggregation of the microtubule-associated protein Tau is closely associated with
tauopathies, including Alzheimer's disease and chronic traumatic encephalopathy. The …
tauopathies, including Alzheimer's disease and chronic traumatic encephalopathy. The …
Deciphering the mechanisms of HPV E6 mutations in the destabilization of E6/E6AP/p53 complex
In epithelial tumors, oncoprotein E6 binds with the ubiquitin ligase E6AP to form E6/E6AP
heterodimer; then this heterodimer recruits p53 to form E6/E6AP/p53 heterotrimer and …
heterodimer; then this heterodimer recruits p53 to form E6/E6AP/p53 heterotrimer and …