Catch me if you can: how AML and its niche escape immunotherapy
In spite of the remarkable progress in basic and preclinical studies of acute myeloid
leukemia (AML), the five-year survival rate of AML patients remains poor, highlighting the …
leukemia (AML), the five-year survival rate of AML patients remains poor, highlighting the …
Single-cell analysis reveals altered tumor microenvironments of relapse-and remission-associated pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistance
Leukemias are refractory hematological malignancies, characterized by marked intrinsic
heterogeneity which poses significant obstacles to effective treatment. However, traditional …
heterogeneity which poses significant obstacles to effective treatment. However, traditional …
Impaired SARS-CoV-2 Variant Neutralization and CD8+ T-cell Responses Following 3 Doses of mRNA Vaccines in Myeloma: Correlation with Breakthrough …
MI Azeem, AK Nooka, U Shanmugasundaram… - Blood cancer …, 2023 - AACR
Patients with multiple myeloma (MM) mount suboptimal neutralizing antibodies (nAb)
following 2 doses of SARS-CoV-2 mRNA vaccines. Currently, circulating SARS-CoV-2 …
following 2 doses of SARS-CoV-2 mRNA vaccines. Currently, circulating SARS-CoV-2 …
Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis
Different driver mutations and/or chromosomal aberrations and dysregulated signaling
interactions between leukemia cells and the immune microenvironment have been …
interactions between leukemia cells and the immune microenvironment have been …
A multidimensional analysis reveals distinct immune phenotypes and the composition of immune aggregates in pediatric acute myeloid leukemia
Because of the low mutational burden and consequently, fewer potential neoantigens,
children with acute myeloid leukemia (AML) are thought to have a T cell-depleted or …
children with acute myeloid leukemia (AML) are thought to have a T cell-depleted or …
Aberrant extrafollicular B cells, immune dysfunction, myeloid inflammation, and MyD88-mutant progenitors precede Waldenstrom macroglobulinemia
Waldenstrom macroglobulinemia (WM) and its precursor IgM gammopathy are distinct
disorders characterized by clonal mature IgM-expressing B-cell outgrowth in the bone …
disorders characterized by clonal mature IgM-expressing B-cell outgrowth in the bone …
Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML
S Fujii, T Kawamata, K Shimizu, J Nakabayashi… - Molecular Therapy …, 2022 - cell.com
Strategies integrating activation of innate and adaptive immunity against cancer are desired.
We established a novel platform, Wilms' tumor antigen 1 (WT1)-expressing artificial adjuvant …
We established a novel platform, Wilms' tumor antigen 1 (WT1)-expressing artificial adjuvant …
Periodontal ligament cells under mechanical force regulate local immune homeostasis by modulating Th17/Treg cell differentiation
J Lin, J Huang, Z Zhang, X Yu, X Cai, C Liu - Clinical Oral Investigations, 2022 - Springer
Objectives Improper orthodontic force often causes root resorption or destructive bone
resorption. There is evidence that T helper 17 (Th17) cells and regulatory T (Treg) cells may …
resorption. There is evidence that T helper 17 (Th17) cells and regulatory T (Treg) cells may …
B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12
R Hunter, KJ Imbach, C Zhou, J Dougan… - Scientific Reports, 2022 - nature.com
Immunotherapies have revolutionized the treatment of B-cell acute lymphoblastic leukemia
(B-ALL), but the duration of responses is still sub-optimal. We sought to identify mechanisms …
(B-ALL), but the duration of responses is still sub-optimal. We sought to identify mechanisms …