Asymmetric lipid membranes: towards more realistic model systems
D Marquardt, B Geier, G Pabst - Membranes, 2015 - mdpi.com
Despite the ubiquity of transbilayer asymmetry in natural cell membranes, the vast majority
of existing research has utilized chemically well-defined symmetric liposomes, where the …
of existing research has utilized chemically well-defined symmetric liposomes, where the …
Interleaflet coupling, pinning, and leaflet asymmetry—major players in plasma membrane nanodomain formation
T Fujimoto, I Parmryd - Frontiers in cell and developmental biology, 2017 - frontiersin.org
The plasma membrane has a highly asymmetric distribution of lipids and contains dynamic
nanodomains many of which are liquid entities surrounded by a second, slightly different …
nanodomains many of which are liquid entities surrounded by a second, slightly different …
Transbilayer lipid interactions mediate nanoclustering of lipid-anchored proteins
Understanding how functional lipid domains in live cell membranes are generated has
posed a challenge. Here, we show that transbilayer interactions are necessary for the …
posed a challenge. Here, we show that transbilayer interactions are necessary for the …
GPI-anchored protein organization and dynamics at the cell surface
The surface of eukaryotic cells is a multi-component fluid bilayer in which
glycosylphosphatidylinositol (GPI)-anchored proteins are an abundant constituent. In this …
glycosylphosphatidylinositol (GPI)-anchored proteins are an abundant constituent. In this …
Intrinsic curvature-mediated transbilayer coupling in asymmetric lipid vesicles
B Eicher, D Marquardt, FA Heberle, I Letofsky-Papst… - Biophysical journal, 2018 - cell.com
We measured the effect of intrinsic lipid curvature, J 0, on structural properties of asymmetric
vesicles made of palmitoyl-oleoyl-phosphatidylethanolamine (POPE; J 0< 0) and palmitoyl …
vesicles made of palmitoyl-oleoyl-phosphatidylethanolamine (POPE; J 0< 0) and palmitoyl …
Model membrane systems used to study plasma membrane lipid asymmetry
It is well known that the lipid distribution in the bilayer leaflets of mammalian plasma
membranes (PMs) is not symmetric. Despite this, model membrane studies have largely …
membranes (PMs) is not symmetric. Despite this, model membrane studies have largely …
Transbilayer colocalization of lipid domains explained via measurement of strong coupling parameters
When micron-scale compositional heterogeneity develops in membranes, the distribution of
lipids on one face of the membrane strongly affects the distribution on the other. Specifically …
lipids on one face of the membrane strongly affects the distribution on the other. Specifically …
Lipid Acyl Chain cis Double Bond Position Modulates Membrane Domain Registration/Anti-Registration
S Zhang, X Lin - Journal of the American Chemical Society, 2019 - ACS Publications
Inter-leaflet coupling is critical to control the dynamics of membrane domain registration/anti-
registration, which is important in maintaining proper biological functions. Factors such as …
registration, which is important in maintaining proper biological functions. Factors such as …
Roles of interleaflet coupling and hydrophobic mismatch in lipid membrane phase-separation kinetics
Characterizing the nanoscale dynamic organization within lipid bilayer membranes is
central to our understanding of cell membranes at a molecular level. We investigate phase …
central to our understanding of cell membranes at a molecular level. We investigate phase …
Live cell plasma membranes do not exhibit a miscibility phase transition over a wide range of temperatures
Lipid/cholesterol mixtures derived from cell membranes as well as their synthetic
reconstitutions exhibit well-defined miscibility phase transitions and critical phenomena near …
reconstitutions exhibit well-defined miscibility phase transitions and critical phenomena near …