In utero, fetal lung epithelial cells actively secrete Cl− ions into the lung air spaces while Na+
ions follow passively to maintain electroneutrality. This process, driven by an …

Over the past decade, there has been an explosion in the number of membrane transport
proteins that have been shown to be sensitive to the abundance of phosphoinositides in the …

Small G proteins exist in eukaryotes from yeast to human and constitute the Ras superfamily
comprising more than 100 members. This superfamily is structurally classified into five …

The central goal of this overview article is to summarize recent findings in renal epithelial
transport, focusing chiefly on the connecting tubule (CNT) and the cortical collecting duct …

Many clinical and preclinical studies report higher prevalence and severity of chronic pain in
females. We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE 2 as a …

In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the
expression of membrane targets such as the subunits of the epithelial Na+ channel, in …

The mineralocorticoid receptor (MR) belongs to the steroid hormone receptor family and
classically functions as a ligand-dependent transcription factor. It is involved in water …

Many clinical and preclinical studies report an increased prevalence and severity of chronic
pain among females. Here, we identify a sex-hormone-controlled target and mechanism that …

Growing evidence implicates a key role for extracellular nucleotides in cellular regulation,
including of ion channels and renal function, but the mechanisms for such actions are …

TRPV1 and TRPA1 have traditionally been considered to function independently from each
other as homomers, but their extensive co-expression in sensory neurons and recent …