Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic
function by mediating the homing of progenitor cells in the bone marrow and regulating their …

Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …

Platelets serve as “first responders” during normal wounding and homeostasis. Arising from
bone marrow stem cell lineage megakaryocytes, anucleate platelets can influence …

CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …

Macrophage migration‐inhibitory factor (MIF) is a pleiotropic cytokine with chemokine‐like
functions and is a mediator in numerous inflammatory conditions. Depending on the context …

Globally, one of the major causes of death is the cardiovascular disease (CVD), and
platelets play an important role in thrombosis and atherosclerosis that led to death. Platelet …

Blood clotting is a finely regulated process that is essential for hemostasis. However, when
dysregulated or spontaneous, it promotes thrombotic disorders. The fact that these are …

The concept of platelets as important players in the process of atherogenesis has become
increasingly accepted due to accumulating experimental and clinical evidence. Despite the …

Platelets play a significant role in atherothrombosis. Proprotein convertase subtilisin/kexin
type 9 (PCSK9) is critically involved in the regulation of LDL metabolism and interacts with …